Genotype Viewer

Analysis Group	Condition; Aged mice (B6/NJcl)
Analysis Group Description	Phenotypic differences of C57BL/6NJcl strain between early and late age have been analyzed in this analysis group. Test mice were produced by the natural mating and reared under the JMC standard housing conditions.

Procedure	Hematology Blood collection for hematological test v2
Pipeline	IMPC_adult_v2-LaterOnset	Screen Age (week)	16-56w

Strain	Associated Gene(s)	Housing SOP(s) and SDOP(s)
	C57BL/6NJcl		Mouse husbandry (RIKEN BRC)

Strain	C57BL/6NJcl	Strain description
Associated Gene(s)		This strain was provided from CLEA Japan and has been maintained by natural mating for two generations.
Housing SOP(s) and SDOP(s)	Mouse husbandry (RIKEN BRC)
Tested Day (Age)	2015/11/24 - 2016/08/29 (16.36 - 56.64)

Strain	Condition 1	Pipeline(s)	Tested Day (Age)
IMPC_adult_v2-LaterOnset
C57BL/6NJcl	Late	♀: 10 ♂: 8	2015/11/24 - 2016/08/29 (16.36 - 56.64)
Early	♀: 14 ♂: 11

Parameter	Difference	Supplement
Percent of basophils (BASO)	NS
Percent of eosinophils (EOS)	NS
Hematocrit (HCT)	S
Hemoglobin (HGB)	S
Percent of Large Unstained Cells (LUC)	S
Percent of lymphocytes (LYMP)	NS
Mean corpuscular hemoglobin (MCH)	S
Mean cell hemoglobin concentration (MCHC)	NS
Mean cell volume (MCV)	S
Percent of monocytes (MONO)	NS
Mean platelet volume (MPV)	S
Absolute number of basophils (BASO number)	NS
Absolute number of eosinophils (EOS number)	S
Percent of neutrophils (NEUT)	NS
Absolute number of Large Unstained Cells (LUC number)	S
Absolute number of lymphocytes (LYMP number)	S
Absolute number of monocytes (MONO number)	S
Absolute number of neutrophils (NEUT number)	S
Absolute number of reticulocytes (Retic number)	S
Platelet count (PLT)	S
Red blood cell count (RBC)	S
Red blood cell distribution width (RDW)	S
Percent of reticulocytes (Retic)	S
White blood cell count (WBC)	S

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Red blood cell count (RBC), Hemoglobin (HGB), Hematocrit (HCT), Mean cell volume (MCV), Mean corpuscular hemoglobin (MCH), Mean platelet volume (MPV) and Absolute number of eosinophils (EOS number) were decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early). White blood cell count (WBC), Absolute number of neutrophils (NEUT number), Absolute number of lymphocytes (LYMP number) and Absolute number of monocytes (MONO number) were decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only female. Platelet count (PLT), Percent of reticulocytes (Retic), Absolute number of reticulocytes (Retic number) and Percent of Large Unstained Cells (LUC) were increased in 56-week-old mice (Late) relative to 16-week-old mice (Early). Absolute number of Large Unstained Cells (LUC number) was increased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only female. Red blood cell distribution width (RDW) was increased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only male.

comment

Red blood cell count (RBC), Hemoglobin (HGB), Hematocrit (HCT), Mean cell volume (MCV), Mean corpuscular hemoglobin (MCH), Mean platelet volume (MPV) and Absolute number of eosinophils (EOS number) were decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early). White blood cell count (WBC), Absolute number of neutrophils (NEUT number), Absolute number of lymphocytes (LYMP number) and Absolute number of monocytes (MONO number) were decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only female. Platelet count (PLT), Percent of reticulocytes (Retic), Absolute number of reticulocytes (Retic number) and Percent of Large Unstained Cells (LUC) were increased in 56-week-old mice (Late) relative to 16-week-old mice (Early). Absolute number of Large Unstained Cells (LUC number) was increased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only female. Red blood cell distribution width (RDW) was increased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only male.