Phenotyping platform of JMC
Phenotyping platform
In Japan Mouse Clinic, we have developed the two pipelines which are constructed with comprehensive test items.
Pipeline 1
Comprehensive test items examining metabolic, blood/hematic, osseous/skeletal, cancer, cardiovascular, sensory, skin/fur, and neural/behavioral characteristics, construct pipeline 1.
| Comprehensive screen | Test ID | Screens | Methods | Age(weeks) | |||||||||||||||||||
| 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | |||||
| P1-01 | Morphology/ Behavioral/ Sensory |
Modified-SHIRPA |
|||||||||||||||||||||
| P1-02 | Blood | Hematological test | |||||||||||||||||||||
| P1-03 | Clinical biochemical test | ||||||||||||||||||||||
| P1-04 | Metabolism | IPGTT (Intra-peritoneal glucose tolerance test) | |||||||||||||||||||||
| P1-05 | Adipocytokine test※ | ||||||||||||||||||||||
| P1-06 | Sensory | Funduscopy | |||||||||||||||||||||
| P1-07 | Morphology | X-ray | |||||||||||||||||||||
| P1-08 | Metabolism | Body fat percentage and Bone Mineral Density (DEXA) | |||||||||||||||||||||
| P1-09 | Cardiovascular | ECG (Electrocardiography) | |||||||||||||||||||||
| P1-10 | Immunology | FACS | |||||||||||||||||||||
| P1-11 | Pathology | Autopsy, Histology | |||||||||||||||||||||
※Optional test
Pipeline 2
|
Behavioral screen |
Test ID | Screens | Methods | Age(weeks) | |||||||||||
| 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | |||||||
| P2-01 | Behavior/ Neurology/ Psychiatry |
Light/dark transition | |||||||||||||
| P2-02 | Open-field test | ||||||||||||||
| P2-03 | Crawley's social interaction test | ||||||||||||||
| P2-04 | Home-cage activity | ||||||||||||||
| P2-05 | Y maze | ||||||||||||||
| P2-06 | Fear-conditioning test | ||||||||||||||
| P2-07 | ASR/PPI | ||||||||||||||
