Publications
2023
Son R., Yamazawa K., Oguchi A., Suga M., , Yanagita M., Murakawa Y., Kume S. Morphomics via next-generation electron microscopy. J Mol Cell Biol 2023: mjad081. (doi: 10.1093/jmcb/mjad081)
Yamada M., Nitta Y., Uehara T., Suzuki H., Miya F., Takenouchi T., , Ayabe S., Yoshiki A., Maeno A., Saga Y., , , Okamoto N., Kosaki K., Sugie A. Heterozygous loss-of-function DHX9 variants are associated with neurodevelopmental disorders: Human genetic and experimental evidences. Eur J Med Genet 2023, 66: 104804. (doi: 10.1016/j.ejmg.2023.104804)
Oestereicher MA., Wotton JM., Ayabe S., About GB., Cheng TK., Choi JH., Clary D., Dew EM., Elfertak L., Guimond A., Mashhadi HH., Heaney JD., Kelsey L., Keskivali-Bond P., Gomez FL., Marschall S., McFarland M., Meziane H., Fuentes VM., Nam KH., Nichtová Z., Pimm D., Bower L., Prochazka J., Rozman J., Santos L., Stewart M., Tanaka N., Ward CS., Willett AME., Wilson R., Braun RE., Dickinson ME., Flenniken AM., Herault Y., Lloyd KCK., Mallon AM., McKerlie C., Murray SA., Nutter LMJ., Sedlacek R., Seong JK., Sorg T., , Wells S., Schneltzer E., Fuchs H., Gailus-Durner V., Angelis MH., White JK., Spielmann N. Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice. Mammalian Genome 2023, 34: 180-199. (doi: 10.1007/s00335-023-09995-y)
Lin CW., Ellegood J., Tamada K., , Konda M., Takeshita K., Atarashi K., Lerch JP., Wakana S., McHugh TJ., Takumi T. An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development. Molecular Psychiatry 2023, 28: 1932-1945. (doi: 10.1038/s41380-023-01999-z)
Sato Y., , Yanagita M. Tertiary lymphoid tissues: a regional hub for kidney inflammation. Nephrol Dial Transplant. 2023, 38: 26-33. (doi: 10.1093/ndt/gfab212)
2022
Kunishima N., Takeda Y., Hirose R., Kume S., Maeda M., Oguchi A., Yanagita M., , , Kataoka Y., Murakawa Y., Ito K., Omote K. Compact laboratory-based X-ray microscope enabling nondestructive 3D structure acquisition of mouse nephron with high speed and better user accessibility. Microscopy (Oxford Journals) 2022, 71: 315-323. (doi: 10.1093/jmicro/dfac033)
Mizumoto T., Yoshizawa T., Sato Y., Ito T., Tsuyama T., Satoh A., Araki S., Tsujita K., , Oike Y., Yamagata K. SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice. Cells 2022, 11: 3609. (doi: 10.3390/cells11223609)
Miyasaka Y., Okuda K., , Motegi H., Wakana S., Ohno T. A novel ENU-induced Cpox mutation causes microcytic hypochromic anemia in mice. Experimental Animals 2022, 71: 433-441. (doi: 10.1538/expanim.22-0032)
Sato Y., Tsuyusaki M., Takahashi-Iwanaga H., Fujisawa R., Masamune A., Hamada S., Matsumoto R., Tanaka Y., Kakuta Y., Yamaguchi-Kabata Y., , Wakana S., Shimura T., Kobayashi R., Shinoda Y., Goitsuka R., Maezawa S., Sadakata T., Sano Y., Furuichi T. Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice. Front Mol Biosci. 2022, 9: 1040237. (doi: 10.3389/fmolb.2022.1040237)
Watanabe C., , Ichiyama Y., Okamura E., Tsukiyama-Fujii S., Tsukiyama T., Matsumoto S., Matsushita J., Azami T., Kubota Y., Ohji M., Sugiyama F., Takahashi S., Mizuno S., , Mizutani K., Ema M. Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice. Life (Basel) 2022, 12: 1730. (doi: 10.3390/life12111730)
Hara T., , Ohashi T., , Hijikata A., Watanabe T., Gao M., Ito K., Kawamata S., Azuma S., Yoshigai E., Sumiyoshi Y., Yasuhiro N., Ohara O., Santos HGD., Fukada T. Role of Scl39a13/ZIP13 in cardiovascular homeostasis. PLOS ONE 2022, 17: e0276452. (doi: 10.1371/journal.pone.0276452)
Uemura M., , , , Abe T., Imai K., Nagao S., Kudoh M., Yoshizawa K., , Kiyonari H., Wakana S., Hirano S. Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour. Scientific Reports 2022, 12: 11933. (doi: 10.1038/s41598-022-16106-5)
Hashimoto D., Fujimoto K., Morioka S., Ayabe S., Kataoka T., Fukumura R., Ueda Y., Kajimoto M., Hyuga T., Suzuki K., Hara I., Asamura S., Wakana S., Yoshiki A., Gondo Y., , Sasaki T., Yamada G. Establishment of mouse line showing inducible priapism-like phenotypes. Reprod Med Biol. 2022, 21: e12472. (doi: 10.1002/rmb2.12472)
, Kikkawa Y., Yasuda SP., , Usuda D., Kumar V., Takahashi JS., , Masuya H., Wakana S. Characterization of single nucleotide polymorphisms for a forward genetics approach using genetic crosses in C57BL/6 and BALB/c substrains of mice. Experimental Animals 2022, 71: 240-251. (doi: 10.1538/expanim.21-0181)
Hirata T., Kobayashi A., , , , Tomita H., Tokoro Y., Ninomiya A., Fujihara Y., Ikawa M., Maeda Y., Murakami Y., Kizuka Y., Kinoshita T. Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology. J Biol Chem. 2022 , 298: 101720. (doi: 10.1016/j.jbc.2022.101720)
Mizuno-Iijima S., Nakashiba T., Ayabe S., Nakata H., Ike F., Hiraiwa N., Mochida K., Ogura A., Masuya H., Kawamoto S., , Obata Y., Shiroishi T., Yoshiki A. Mouse resources at the RIKEN BioResource Research Center and the National BioResource Project core facility in Japan. Mammalian Genome 2022, 33: 181-191. (doi: 10.1007/s00335-021-09916-x)
2021
Nakano T., Aochi H., Hirasaki M., Takenaka Y., Fujita K., , Soma H., Kamezawa H., Koizumi T., , Inomata R., Okuda A., Murakoshi T., Shimada A. and Inoue I. Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle. Developmental Biology 2021, 478: 222-235. (doi: 10.1016/j.ydbio.2021.07.003)
Zhang C., Clough SJ., Adamah-Biassi EB., Sveinsson MH., Hutchinson AJ., , , Wakana S., Matsumoto YK., Okanoya K., Hudson RL., Kato T., Dubocovich ML., Kasahara T. Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin-proficient C57BL/6J congenic mice. Journal of Pineal Research 2021, 71: e12748. (doi: 10.1111/jpi.12748)
Birling MC., Yoshiki A., Adams D., Ayabe S., Beaudet AL., Bottomley J., Bradley A., Brown SDM., Burger A., Bushell W., Chiani F., Christou S., Codner GF., DeMayo FJ., Dickinson ME., Doe B., Donahue LR., Fray MD., Gambadoro A., Gertsenstein M., Gomez-Segura A., Goodwin LO., Heaney JD., Herault Y., Hrabe de Angelis M., Justice MJ., King RE., Kuhn R., Lee H., Lee YJ., Lloyd KCK., Lorenzo I., Mallon AM., McKerlie C., Meehan TF., Nutter LMJ., Oh GT., Pavlovic G., Ramirez-Solis R., Rosen B., Ryder EJ., Santos LA., Schick J., Seavitt JR., Seong JK., Skarnes WC., Steel K., , Tocchini-Valentini GP, Wardle-jones H., Wattenhofer-donze M., Wells S., Willis BJ., Wood JA., Wurst W., The International Mouse Phenotyping Consortium, Teboul L. and Murray SA. A resource of targeted mutant mouse lines for 5,061 genes. Nature Genetics 2021, 53: 416-419. (doi: 10.1038/s41588-021-00825-y)
2020
Horiai M., Otsuka A., Hidema S., Hiraoka Y., Hayashi R., Miyazaki S., , Mizukami H., Teruyama R., , Bito H., Maejima Y., Shimomura K., and Nishimori K. Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models. Scientific Reports 2020, 10: 22173. (doi: 10.1038/s41598-020-79109-0)
Tanaka S., Ise W., Inoue T., Ito A., Ono C., Shima Y., Sakakibara S., Nakayama M., Fujii K., , Sharif J., Koseki H., Koni PA., Raman I., Li QZ., Kubo M., Fujiki K., Nakato R., Shirahige K., Araki H., Miura F., Ito T., Kawakami E., Baba Y. and Kurosaki T. Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity. Nature Immunology 2020, 21: 950-961. (doi: 10.1038/s41590-020-0700-y)
Matsumura K., Seiriki K., Okada S., Nagase M., Ayabe S., , , , Yasuda Y., Yamamori H., Fujimoto M., Nagayasu K., Yamamoto K., Kitagawa K., Miura H., Gotoda-Nishimura N., Igarashi H., Hayashida M., Baba M., Kondo M., Hasebe S., Ueshima K., Kasai A., Ago Y., Hayata-Takano A., Shintani N., Iguchi T., Sato M., Yamaguchi M., , Wakana S., Yoshiki A., Watabe A., Okano H., Takuma K., Hashimoto R., Hashimoto H. and Nakazawa T. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. Nature Communications 2020, 11: 859. (doi: 10.1038/s41467-020-14697-z)
Terumitsu-Tsujita M., Kitaura H., , Kiyama Y., Goto F., Muraki Y., Ominato S., Hara N., Simankova A., Bizen N., Kashiwagi K., Ito T., Toyoshima Y., Kakita A., Manabe T., Wakana S., Takebayashi H. and Igarashi H. Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model. Journal of Neurochemistry 2020, 154: 25-40. (doi: 10.1111/jnc.14887)
2019
Haselimashhadi H., Mason J., Munoz-Fuentes V., Lopez-Gomez F., Babalola K., Acar E., Kuma V., White J., Flenniken A., King R., Straiton E., Seavitt JR., Gaspero A., Garza A., Christiansen A., Hsu CW., Reynolds C., Lanza D., Lorenzo I., Green J., Gallegos J., Bohat R., Samaco R., Veeraragavan S., Kim JK., Miller G., Fuchs H., Garrett L., Becker L., Kang YK., Clary D., Soo Y., , Tanaka N., Kyoung DS., Bezginov A., Bou About G., Champy MF., Vasseur L., Leblanc S., Meziane H., Selloum M., Reilly P., Spielmann N., Maier H., Gailus-Durner V., Sorg T., Masuya H., Obata Y., Heaney J., Dickinson M., Wurst W., Tocchini-Valentini G., Lloyd KCK., McKerlie C., Seong JK., Hérault Y., Hrabé de Angelis M., Brown S., Smedley D., Flicek P., Mallon AM., Parkinson H. and Meehan T. Soft Windowing Application to Improve Analysis of High-throughput Phenotyping Data. Bioinformatics 2019, btz744, (doi: org/10.1093/bioinformatics/btz744)
, Mizuma H., Hirose Y., , , , Masuya H., Funato H., Yanagisawa M., Onoe H. and Wakana S. A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain. Disease Models & Mechanisms 2019, 12: dmm038828. (doi: 10.1242/dmm.038828)
Kim K., Suzuki A., Kojima H., Kawamura M., Miya K., Abe M., , , Wakana S., Sakimura K. and Hayashi Y. Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning. Neurobiol Learn Mem. 2019, 157: 86-95. (doi: 10.1016/j.nlm.2018.12.003)
2018
Kishimoto K., , Nishita M., Minami Y., Yamaoka A., Abe T., Shigeta M. and Morimoto M. Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus. Nature Communications 2018, 9: 2816. (doi: 10.1038/s41467-018-05189-2)
Takahashi M., , Sato S. and Kawakami K. Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele. Disease Models & Mechanisms 2018, 11: dmm.034611. (doi: 10.1242/dmm.034611)
, Watanabe R., Maeno A., Ichimura K., , Wakana S., Shiroishi T., Ohba K., Takeda K., Tomita H., Shibahara S. and Yamamoto H. Melanocytes contribute to the vasculature of the choroid. Genes & Genetic Systems 2018, 93: 51-58. (doi: 10.1266/ggs.17-00058)
Rozman J., Rathkolb B., Oestereicher MA., Schütt C., Ravindranath AC., Leuchtenberger S., Sharma S., Kistler M., Willershäuser M., Brommage R., Meehan TF., Mason J., Haselimashhadi H., , Hough T., Mallon AM., Wells S., Santos L., Lelliott CJ., White JK., Sorg T., Champy MF., Bower LR., Reynolds CL., Flenniken AM., Murray SA., Nutter LMJ., Svenson KL., West D., Tocchini-Valentini GP., Beaudet AL., Bosch F., Braun RB., Dobbie MS., Gao X., Herault Y., Moshiri A., Moore BA., Kent LKC., McKerlie C., Masuya H., Tanaka N., Flicek P., Parkinson HE., Sedlacek R., Seong JK., Wang CL., Moore M., Brown SD., Tschöp MH., Wurst W., Klingenspor M., Wolf E., Beckers J., Machicao F., Peter A., Staiger H., Häring HU., Grallert H., Campillos M., Maier H., Fuchs H., Gailus-Durner V., Werner T. and Hrabe de Angelis M. Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nature Communications 2018, 9: 288. (doi: 10.1038/s41467-017-01995-2)
Moore BA., Leonard BC., Sebbag L., Edwards SG., Cooper A., Imai DM., Straiton E., Santos L., Reilly C., Griffey SM., Bower L., Clary D., Mason J., Roux MJ., Meziane H., Herault Y., , McKerlie C., Flenniken AM., Nutter LMJ., Berberovic Z., Owen C., Newbigging S., Adissu H., Eskandarian M., Hsu CW., Kalaga S., Udensi U., Asomugha C., Bohat R., Gallegos JJ., Seavitt JR., Heaney JD., Beaudet AL., Dickinson ME., Justice MJ., Philip V., Kumar V., Svenson KL., Braun RE., Wells S., Cater H., Stewart M., Clementson-Mobbs S., Joynson R., Gao X., Suzuki T., Wakana S., Smedley D., Seong JK., Tocchini-Valentini G., Moore M., Fletcher C., Karp N., Ramirez-Solis R., White JK., Hrabe de Angelis M, Wurst W., Thomasy SM., Flicek P., Parkinson H., Brown SDM., Meehan TF., Nishina PM., Murray SA., Krebs MP., Mallon AM., Lloyd KCK., Murphy CJ. and Moshiri A. Identification of genes required for eye development by high-throughput screening of mouse knockouts. Communications Biology 2018, 1: 236. (doi: 10.1038/s42003-018-0226-0)
Shimazu T., , Balan S., , Okuno S., Iwanari H., Suzuki T., Hamakubo T., Dohmae N., Yoshikawa T., Wakana S. and Shinkai Y. Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions. Scientific Reports 2018 8: 1179. (doi: 10.1038/s41598-018-19615-4)
Gotoh H., and Wakana S. Genetic mapping of a male factor subfertility locus on mouse chromosome 4. Mammalian Genome 2018, 29: 663-669. (doi: 10.1007/s00335-018-9773-4)
2017
Fujihira H., Masahara-Negishi Y., , Harada Y., Chengcheng H., Wakana S., Taniguchi N., Kondoh G., Yamashita T., Funakoshi Y. and Suzuki T. Lethality of mice bearing a knockout of the Ngly1-gene is rescued by the additional deletion of the Engase gene. PLoS Genetics 2017, 13: e1006696 (doi: 10.1371/journal.pgen.1006696)
Naruse C., Shibata S., , Kawaguchi T., Abe K., Sugihara K., Kato T., Nishiuchi T., Wakana S., Ikawa M. and Asano M. New insights on the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB Journal 2017, 31: 2252-2266. (doi:10.1096/fj.201600642R)
Kitazawa M., , Kaneko-Ishino T. and Ishino F. Severe damage to the placental fetal capillary network causes mid to late fetal lethality and reduction of placental size in Peg11/Rtl1 KO mice. Genes to Cells 2017, 22: 174-188. (doi: 10.1111/gtc.12465)
Kataoka T., , Amano T., Maeno A., Wakana S. and Shiroishi T. Genetic dissection of trabecular bone formation with the B6-MSM consomic mouse strains. G3: Genes, Genomes, Genetics 2017, 7: 3449-3457. (doi: 10.1534/g3.117.300213)
Meehan TF., Conte N., West DB., Jacobsen JO, Mason J., Warren J., Chen C-K., Tudose I., Relac M., Matthews P., Karp N., Santos L., Fiegel T., Ring N., Westerberg H., Greenaway S., Sneddon D., Morgan H., Codner GF., Stewart ME, Brown J, Horner N., , Haendel M., Washington N., Mungall CJ., Reynolds CL., Gallegos J., Gailus-Durner V., Sorg T., Pavlovic G., Bower LB., Moore M., Morse I., Gao X., Tocchini-Valentini GP., Obata Y., Cho SY., Seong JK., Seavitt J., Beaudet AL., Dickinson ME., Herault Y., Wurst W., Hrabé de Angelis M., Lloyd KCK., Flenniken AM., Nutter LMJ., Newbigging S., McKerlie C., Justice MJ., Murray SA, Svenson KL., Braun RE., White JK., Bradley A., Flicek P., Wells S., Skarnes WC., Adams DJ., Parkinson H., Mallon AM., Brown SDM., Smedley D. Disease Model Discovery from 3,328 Gene Knockouts by The International Mouse Phenotyping Consortium. Nature Genetics 2017, 49: 1231-1238. (doi: 10.1038/ng.3901)
Bowl MR., Simon MM., Ingham NJ., Greenaway S., Santos L., Cater H., Taylor S., Mason J., Kurbatova N., Pearson S., Bower LR., Clary DA., Meziane H., Reilly P., Minowa O., Kelsey L., , Tocchini-Valentini GP., Gao X., Bradley A., Skarnes WC., Moore M., Beaudet AL., Justice MJ., Seavitt J., Dickinson ME., Wurst W., Hrabé de Angelis M., Herault Y., Wakana S., Nutter LMJ., Flenniken AM., McKerlie C., Murray SA., Svenson KL., Braun RE., West DB., Lloyd KCK., Adams DJ., White J., Karp N., Flicek P., Smedley D., Meehan TF., Parkinson HE., Teboul LM., Wells S., Steel KP., Mallon AM., Brown SDM. A large-scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nature Communications 2017, 8: 886. (doi: 10.1038/s41467-017-00595-4)
Karp NA., Mason J., Beaudet AL., Benjamini Y., Bower L., Braun RE., Brown SDM., Chesler EJ., Dickinson ME., Flenniken AM., Fuchs H., Gao X., Guo S., Greenaway S., Heller R., Herault Y., Hrabé de Angelis M., Justice MJ., Kurbatova N., Lelliott CJ., Lloyd KCK., Mallon AM., Mank JE., Masuya H., McKerlie C., Meehan TF., Mott RF., Murray SA., Parkinson H., Ramirez-Solis R., Santos L., Seavitt JR., Smedley D., Sorg T., Speak AO., Steel KP., Svenson KL., , Wakana S., West D., Wells S., Westerberg H., Yaacoby S. and White JK. Prevalence of sexual dimorphism in mammalian phenotypic traits. Nature Communications 2017, 8: 15475. (doi: 10.1038/ncomms15475)
, Miyake K., Kohda T., Kaneda H., Hirasawa T., , , Kashimura M., Kobayashi K., Ishino F., Kubota T. and Wakana S. Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny. Genes & Nutrition 2017, 12: 1. (doi: 10.1186/s12263-016-0550-2)
Hirose M., Hasegawa A., Mochida K., Matoba S., Hatanaka Y., Inoue K., Goto T., Kaneda H., , , Abe K., Uenoyama Y., Tsukamura H., Wakana S., Honda A. and Ogura A. CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene. Scientific Reports 2017, 7: 42476. (doi: 10.1038/srep42476)
Okumura K., Saito M., Yoshizawa Y., Munakata H., Isogai E., , Wakana S., Yamaguchi M., Shitara H., Taya C., Karaplis AC., Kominami R. and Wakabayashi Y. The parathyroid hormone regulates skin tumour susceptibility in mice. Scientific Reports 2017, 7: 11208. (doi: 10.1038/s41598-017-11561-x)
Ohnishi T., , Ohba H., Shimamoto C., Iwayama Y., Wakana S. and Yoshikawa T. A spontaneous and novel Pax3 mutant mouse that models Waardenburg syndrome and neural tube defects. Gene 2017, 607: 16-22. (doi: 10.1016/j.gene.2016.12.037)
2016
Dickinson ME., Flenniken AM., Ji X., Teboul L., Wong MD., White JK., Meehan TF., Weninger WJ., Westerberg H., Adissu H., Baker CN., Bower L., Brown JM., Caddle LB., Chiani F., Clary D., Cleak J., Daly MJ., Denegre JM., Doe B., Edie SM., Fuchs H., Gailus-Durner V., Galli A., Gambadaro A., Gallegos J., Guo S., Horner NR., Hsu Cw., Johnson SJ., Kalaga S., Keith LC., Lanoue L., Lawson TN., Lek M., Mark M., Marschall S., Mason J., McElwee ML., Newbigging S., Nutter LMJ., Peterson KA., Ramirez-Solis R., Rowland DJ., Ryder E., Samocha KE., Seavitt JR., Selloum M., Szoke-Kovacs Z., , Trainor AG., Tudose I., Wakana S., Warren J., Wendling O., West DB., Wong L., Yoshiki A., , MacArthur DG., Tocchini-Valentini GP., Gao X., Flicek P., Justice M., Parkinson HE., Moore M., Wells S., Braun RE., Svenson K., Hrabé de Angelis M., Herault Y., Mohun T., Mallon AM., Henkelman RM., Brown SD., Adams D., Lloyd KCK., McKerlie C., Beaudet AL., Bucan M. and Murray SA. High-throughput discovery of novel developmental phenotypes. Nature 2016, 537: 508-514. (doi:10.1038/nature19356)
Funato H., Miyoshi C., Fujiyama T., Kanda T., Sato M., Wang Z., Ma J., Nakane S., Tomita J., Ikkyu A., Kakizaki M., Hotta-Hirashima N., Kanno S., Komiya H., Asano F., Honda T., Kim SJ., Harano K., Muramoto H., Yonezawa T., Mizuno S., Miyazaki S., Connor L., Kumar V., , Suzuki T., Watanabe A., Abe M., Sugiyama F., Takahashi S., Sakimura K., Hayashi Y., Liu Q., Kume K., Wakana S., Takahashi1 JS. and Yanagisawa M. Forward-genetics analysis of sleep in randomly mutagenized mice. Nature 2016, 539: 378-383. (doi:10.1038/nature20142)
Yoshizaki K., , Kimura R., Tucci V., Kaneda H., Wakana S. and Osumi N. Paternal Aging Affects Behavior in Pax6 Mutant Mice: A Gene/Environment Interaction in Understanding Neurodevelopmental Disorders. PLOS ONE 2016, 11: e0166665. (doi: 10.1371/journal.pone.0166665)
Ohba K., Takeda K., , Suzuki T., Wakana S., Suzuki T., Yamamoto H. and Shibahara S. Microphthalmia-associated transcription factor ensures the elongation of axons and dendrites in the mouse frontal cortex. Genes to Cells 2016, 21:1365-1379. (doi: 10.1111/gtc.12450)
Liu Y., Maekawa T., Yoshida K., , Kaneda H., Wakana S. and Ishii S. ATF7 ablation prevents diet-induced obesity and insulin resistance. Biochem Biophys Res Commun. 2016, 478: 696-702. (doi: 10.1016/j.bbrc.2016.08.009)
Yoshikawa F., Sato Y., Tohyama K., Akagi T., , Sadakata T., Tanaka M., Shinoda Y., Hashikawa T., Itohara S., Sano Y., Ghandour MS., Wakana S. and Furuichi T. Mammalian-Specific central myelin protein Opalin is redundant for normal myelination: structural and behavioral assessments. PLOS ONE 2016, 11: e0166732. (doi: 10.1371/journal.pone.0166732)
Yasuda T., Fukada T., Nishida K., Nakayama M., Matsuda M., , Dainichi T., Fukuda S., Kabashima K., Nakaoka S., Bin BH., Kubo M., Ohno H., Hasegawa T., Ohara O., Koseki H., Wakana S. and Yoshida H. Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis. Journal of Clinical Investigation 2016, 126: 2064-76. (doi: 10.1172/JCI82887)
Hossain MS., Asano F., Fujiyama T., Miyoshi C., Sato M., Ikkyu A., Kanno S., Hotta N., Kakizaki M., Honda T., Kim SJ., Komiya H., , Suzuki T., Kobayashi K., Kaneda H., Kumar V., Takahashi JS., Wakana S., Funato H. and Yanagisawa M. Identification of mutations through dominant screening for obesity using C57BL/6 substrains. Scientific Reports 2016, 6: 32453. (doi: 10.1038/srep32453)
Xie Z., Kitamoto A., , Shiroishi T. and Gillies D. High-throughput mouse phenotyping using non-rigid registration and robust principal component analysis. Proceedings of SPIE 9784, Biomedical Imaging 2016, Image Processing, 978415, e1-e8. (doi: 10.1117/12.2217155)
2015
and Shiroishi T. GSDM family genes meet autophagy. Biochemical Journal 2015, 469: e5-e7. (doi: 10.1042/BJ20150558)
Xie Z., Liang X., Guo L., Kitamoto A., , Shiroishi T. and Gillies D. An automatic classification framework for ventricular septal defects: a pilot study on high-throughput mouse embryo cardiac phenotyping. Journal of Medical Imaging 2015, 2: 041003. (doi: 10.1117/1.JMI.2.4.041003)
Liang X., Xie Z., , Shiroishi T., Kitamoto A. Towards high-throughput mouse embryonic phenotyping: a novel approach to classifying ventricular septal defects. Proceedings of SPIE 9413, Medical Imaging 2015: Image Processing, 94131V, 2015, 66: 1-8. (doi: 10.1117/12.2081148)
Irie M., Yoshikawa M., Ono R., Iwafune H., , , Wakana S., Yamashita Y., Abe T., Ishino F. and Kaneko-Ishino T. Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians. PLoS Genetics 2015, 11: e1005521. (doi: 10.1371/journal.pgen.1005521)
Hirawatari K., Hanzawa N., , Wakana S. and Gotoh H. A Cascade of epistatic interactions regulating teratozoospermia in mice. Mammalian Genome 2015, 26: 248-56. (doi: 10.1007/s00335-015-9566-y)
Uchimura A., Higuchi M., Minakuchi Y., Ohno M., Toyoda A., Fujiyama A., , Wakana S., Nishino J. and Yagi T. Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice. Genome Research 2015, 25: 1125-34. (doi: 10.1101/gr.186148.114)
Kamimura D., Katsunuma K., Arima Y., Atsumi T., Jiang JJ., Bando H., Meng J., Sabharwal L., Stofkova A., Nishikawa N., Suzuki H., Ogura H., Ueda N., Tsuruoka M., Harada M., Kobayashi J., Hasegawa T., Yoshida H., Koseki H., , Wakana S., Nishida K., Kitamura H., Fukada T., Hirano T. and Murakami M. KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR. Nature Communications 2015, 6: 7474. (doi: 10.1038/ncomms8474)
Konno D., Kasukawa T., Hashimoto K., Itoh T., Suetsugu T., , Wakana S., Carninci P. and Matsuzaki F. STAP cells are derived from ES cells. Nature 2015, 525: E4-5. (doi: 10.1038/nature15366)
2014
, Amano T. and Shiroishi T. The Hand2 gene dosage effect in developmental defects and human congenital disorders. Curr Top Dev Biol. 2014, 110: 129-152. (doi: 10.1016/B978-0-12-405943-6.00003-8)
Nabeshima Y., Washida M., , Yurugi K., Ohnishi M., Maeno A., St-Arnaud S., Shiroishi T., Razzaque MS., Imura A. and Nabeshima Y. Calpain 1 inhibitor, BDA-410 restores a-klotho deficient phenotypes resembling to human aging related syndromes. Scientific Reports 2014, 4: 5847. (doi: 10.1038/srep05847)
Kono H., , Osada N., Suzuki H., Abe K., Moriwaki K., Ohta K. and Shiroishi T. Prdm9 polymorphism unveils mouse evolutionary tracks. DNA Research 2014, 21: 315-326. (doi: 10.1093/dnares/dst059)
Liang X., Xie Z., Kitamoto A., , Shiroishi T. and Kotagiri R. A novel atlas-based approach to the detection of mouse embryo ventricular septal defects. Medical image computing and computer-assisted intervention 2014, 44-45.
Naruse M., Ono R., Irie M., Nakamura K., , Hino T., Oda K., Kashimura M., , Wakana S., Yokoyama M., Ishino F. and Kaneko-Ishino T. Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition. Development 2014, 141: 4763-4771. (doi: 10.1242/dev.114520)
Arime Y., Fukumura R., , Mekada K., Yoshiki A., Wakana S., Gondo Y. and Akiyama K. Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice. Behavioral and Brain Functions 2014, 10: 45. (doi: 10.1186/1744-9081-10-45)
Okumura K., Saito M., Isogai E., , Wakana S., Kominami R. and Wakabayashi Y. Congenic mapping and allele-specific alteration analysis of Stmm1 locus conferring resistance to early-stage chemically induced skin papillomas. PLOS ONE 2014, 9: e97201. (doi: 10.1371/journal.pone.0097201)
Saito M., Okumura K., , Wakana S., Kominami R. and Wakabayashi Y. Identification of Stmm3 locus conferring resistance to late-stage chemically induced skin papillomas on mouse chromosome 4 by congenic mapping and allele-specific alteration analysis. Experimental Animals 2014, 63: 339-348. (doi: 10.1538/expanim.63.339)
2013
, Hosoya M., Fujita M., Iida T., Amano T., Maeno A., Kataoka T., Otsuka T., Tanaka S, Tomizawa S. and Shiroishi T. Over-dosage of Hand2 causes limb and heart defects in human chromosomal disorder, partial trisomy distal 4q. Human Molecular Genetics 2013, 22: 2471-2481. (doi: 10.1093/hmg/ddt099)
Tanaka S., Mizushina Y., Kato Y., and Shiroishi T. Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome. G3: Genes, Genomes, Genetics 2013, 3: 1843-1850. (doi: 10.1534/g3.113.007393)
Roy S., Liang X., Kitamoto A., , Shiroishi T. and Brown MS. Phenotype detection in morphological mutant mice using deformation features. Medical image computing and computer-assisted intervention 2013, 16: 437-444.
Suzuki T., , , Motegi H., , Masuya H., Wakana S. Pheno-Pub: a total support system for the publication of mouse phenotypic data on the web. Mammalian Genome 2013, 24: 473-83. (doi: 10.1007/s00335-013-9482-y)
Umemori J., Takao K., Koshimizu H., Hattori S., , Wakana S. and Miyakawa T. ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response. BMC Research Notes 2013, 6: 203. (doi: 10.1186/1756-0500-6-203)
Toki H., Inoue M., Motegi H., Minowa O., Kanda H., Yamamoto N., Ikeda A., Karashima Y., Matsui J., Kaneda H., , Suzuki T., Wakana S., Masuya H., Gondo Y., Shiroishi T., Akiyama T., Yao R. and Noda T. Novel mouse model for Gardner syndrome generated by a large-scale N-ethyl-N-nitrosourea mutagenesis program. Cancer Science 2013, 104: 937-944. (doi: 10.1111/cas.12161)
