Technology and Development Teams for Mouse Phenotype Analysis develops "Mouse Clinic" which is a phenotype analysis platform for genetically modified mice that systematically examines more than 700 items, aiming to understand the pathology of human diseases and elucidate gene functions. The Team participates in the International Mouse Phenotyping Consortium (IMPC), publishes the results of the phenotype analyses, and develops new technologies on phenotyping analyses.


Team Mission

  • Development of systematic and comprehensive phenotyping platform for mice
  • International contribution through participation in the IMPC
  • Provision of international standardized phenotyping methods to the domestic research community
  • Development of new phenotyping methods
IMPC_logo Japan Mouse Clinic is one of institutional members of IMPC (International Mouse Phenotyping Consortium).
Enter the page "Activity for IMPC" to search phenotype and development information of IMPC Knockout mouse strains.


What's news

2021/07/29 Dr. Shibuya and Dr. Tamura published a technical article entitled "New frontiers of X-ray imaging in the life sciences" in the Japanese journal "The Cell" (Vol.53, No.9, 2021).
2021/07/29 A research paper on "Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle." that Dr. Tamura and Dr. Shibuya conducted an imaging analysis as a collaborator has been published in Developmental Biology. This is a joint research with Saitama Medical University, Nippon Medical University and Tokyo Medical University.
https://doi.org/10.1016/j.ydbio.2021.07.003
2021/07/02 A paper on "Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin-proficient C57BL/6J congenic mice" that Dr. Furuse and Mr. Miura conducted a behavioral analysis and a genome scan, respectively, as a collaborator has been published in Journal of Pineal Research. It is a joint research with RIKEN Center for Brain Science, State University of New York at Buffalo, Tokyo University and Juntendo University.
https://doi.org/10.1111/jpi.12748
https://www.riken.jp/en/news_pubs/research_news/pr/2021/20210624_2/index.html
2021/04/27 The phenotyping pipeline 1 was updated.
2021/04/08 The International Mouse Phenotyping Consortium, in which our team participates, reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles. These results were published in Nature Genetics.
https://doi.org/10.1038/s41588-021-00825-y
2020/12/17 A research paper entitled "Targeting oxytocin receptor (Oxtr)-expressing neurons in the lateral septum to restore social novelty in autism spectrum disorder mouse models" that Dr. Furuse and Dr. Tamura conducted a behavioral analysis as a collaborator has been published in Scientific Reports. This is a collaborative research with several universities, including Fukushima Medical University and Tohoku University.
https://www.nature.com/articles/s41598-020-79109-0
2020/08/04 The RIKEN BRC Website was renewed. With this change, we updated the team website.

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