研究業績

2020

Tanaka S., Ise W., Inoue T., Ito A., Ono C., Shima Y., Sakakibara S., Nakayama M., Fujii K., Miura I., Sharif J., Koseki H., Koni PA., Raman I., Li QZ., Kubo M., Fujiki K., Nakato R., Shirahige K., Araki H., Miura F., Ito T., Kawakami E., Baba Y. and Kurosaki T. Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity. Nature Immunology (Epub 2020 June 22)

Matsumura K., Seiriki K., Okada S., Nagase M., Ayabe S., Yamada I., Furuse T., Shibuya H., Yasuda Y., Yamamori H., Fujimoto M., Nagayasu K., Yamamoto K., Kitagawa K., Miura H., Gotoda-Nishimura N., Igarashi H., Hayashida M., Baba M., Kondo M., Hasebe S., Ueshima K., Kasai A., Ago Y., Hayata-Takano A., Shintani N., Iguchi T., Sato M., Yamaguchi M., Tamura M., Wakana S., Yoshiki A., Watabe A., Okano H., Takuma K., Hashimoto R., Hashimoto H. and Nakazawa T. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. Nature Communications 2020, 11: 859. (doi: 10.1038/s41467-020-14697-z)

Terumitsu-Tsujita M., Kitaura H., Miura I., Kiyama Y., Goto F., Muraki Y., Ominato S., Hara N., Simankova A., Bizen N., Kashiwagi K., Ito T., Toyoshima Y., Kakita A., Manabe T., Wakana S., Takebayashi H. and Igarashi H. Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model. Journal of Neurochemistry 2020, 154: 25-40. (doi: 10.1111/jnc.14887)

2019

Haselimashhadi H., Mason J., Munoz-Fuentes V., Lopez-Gomez F., Babalola K., Acar E., Kuma V., White J., Flenniken A., King R., Straiton E., Seavitt JR., Gaspero A., Garza A., Christiansen A., Hsu CW., Reynolds C., Lanza D., Lorenzo I., Green J., Gallegos J., Bohat R., Samaco R., Veeraragavan S., Kim JK., Miller G., Fuchs H., Garrett L., Becker L., Kang YK., Clary D., Soo Y., Tamura M., Tanaka N., Kyoung DS., Bezginov A., Bou About G., Champy MF., Vasseur L., Leblanc S., Meziane H., Selloum M., Reilly P., Spielmann N., Maier H., Gailus-Durner V., Sorg T., Masuya H., Obata Y., Heaney J., Dickinson M., Wurst W., Tocchini-Valentini G., Lloyd KCK., McKerlie C., Seong JK., Hérault Y., Hrabé de Angelis M., Brown S., Smedley D., Flicek P., Mallon AM., Parkinson H. and Meehan T. Soft Windowing Application to Improve Analysis of High-throughput Phenotyping Data. Bioinformatics 2019, btz744, (doi: org/10.1093/bioinformatics/btz744)

Furuse T., Mizuma H., Hirose Y., Kushida T., Yamada I, Miura I., Masuya H., Funato H., Yanagisawa M., Onoe H. and Wakana S. A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain. Disease Models & Mechanisms 2019, 12: dmm038828. (doi: 10.1242/dmm.038828)

Kim K., Suzuki A., Kojima H., Kawamura M., Miya K., Abe M., Yamada I., Furuse T., Wakana S., Sakimura K. and Hayashi Y. Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning. Neurobiology of Learning and Memory 2019, 157: 86-95. (doi: 10.1016/j.nlm.2018.12.003)

2018

Kishimoto K., Tamura M., Nishita M., Minami Y., Yamaoka A., Abe T., Shigeta M. and Morimoto M. Synchronized mesenchymal cell polarization and differentiation shape the formation of the murine trachea and esophagus. Nature Communications 2018, 9: 2816. (doi: 10.1038/s41467-018-05189-2)

Takahashi M., Tamura M., Sato S. and Kawakami K. Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human omphalocele. Disease Models & Mechanisms 2018, 11: dmm.034611. (doi: 10.1242/dmm.034611)

Shibuya H., Watanabe R., Maeno A., Ichimura K., Tamura M., Wakana S., Shiroishi T., Ohba K., Takeda K., Tomita H., Shibahara S. and Yamamoto H. Melanocytes contribute to the vasculature of the choroid. Genes & Genetic Systems 2018, 93: 51-58. (doi: 10.1266/ggs.17-00058)

Rozman J., Rathkolb B., Oestereicher MA., Schütt C., Ravindranath AC., Leuchtenberger S., Sharma S., Kistler M., Willershäuser M., Brommage R., Meehan TF., Mason J., Haselimashhadi H., The International Mouse Phenotyping Consortium, Hough T., Mallon AM., Wells S., Santos L., Lelliott CJ., White JK., Sorg T., Champy MF., Bower LR., Reynolds CL., Flenniken AM., Murray SA., Nutter LMJ., Svenson KL., West D., Tocchini-Valentini GP., Beaudet AL., Bosch F., Braun RB., Dobbie MS., Gao X., Herault Y., Moshiri A., Moore BA., Kent LKC., McKerlie C., Masuya H., Tanaka N., Flicek P., Parkinson HE., Sedlacek R., Seong JK., Wang CL., Moore M., Brown SD., Tschöp MH., Wurst W., Klingenspor M., Wolf E., Beckers J., Machicao F., Peter A., Staiger H., Häring HU., Grallert H., Campillos M., Maier H., Fuchs H., Gailus-Durner V., Werner T. and Hrabe de Angelis M. Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nature Communications 2018, 9: 288. (doi: 10.1038/s41467-017-01995-2)

Moore BA., Leonard BC., Sebbag L., Edwards SG., Cooper A., Imai DM., Straiton E., Santos L., Reilly C., Griffey SM., Bower L., Clary D., Mason J., Roux MJ., Meziane H., Herault Y., The International Mouse Phenotyping Consortium, McKerlie C., Flenniken AM., Nutter LMJ., Berberovic Z., Owen C., Newbigging S., Adissu H., Eskandarian M., Hsu CW., Kalaga S., Udensi U., Asomugha C., Bohat R., Gallegos JJ., Seavitt JR., Heaney JD., Beaudet AL., Dickinson ME., Justice MJ., Philip V., Kumar V., Svenson KL., Braun RE., Wells S., Cater H., Stewart M., Clementson-Mobbs S., Joynson R., Gao X., Suzuki T., Wakana S., Smedley D., Seong JK., Tocchini-Valentini G., Moore M., Fletcher C., Karp N., Ramirez-Solis R., White JK., Hrabe de Angelis M, Wurst W., Thomasy SM., Flicek P., Parkinson H., Brown SDM., Meehan TF,. Nishina PM., Murray SA., Krebs MP., Mallon AM., Lloyd KCK., Murphy CJ. and Moshiri A. Identification of genes required for eye development by high-throughput screening of mouse knockouts. Communications Biology 2018, 1: 236. (doi: 10.1038/s42003-018-0226-0)

Shimazu T., Furuse T., Balan S., Yamada I., Okuno S., Iwanari H., Suzuki T., Hamakubo T., Dohmae N., Yoshikawa T., Wakana S. and Shinkai Y. Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions. Scientific Reports 2018 8: 1179. (doi: 10.1038/s41598-018-19615-4)

Gotoh H., Miura I. and Wakana S. Genetic mapping of a male factor subfertility locus on mouse chromosome 4. Mammalian Genome 2018, 29: 663-669. (doi: 10.1007/s00335-018-9773-4)

2017

Fujihira H., Masahara-Negishi Y., Tamura M., Harada Y., Chengcheng H., Wakana S., Taniguchi N., Kondoh G., Yamashita T., Funakoshi Y. and Suzuki T. Lethality of mice bearing a knockout of the Ngly1-gene is rescued by the additional deletion of the Engase gene. PLoS Genetics 2017, 13: e1006696 (doi: 10.1371/journal.pgen.1006696)

Naruse C., Shibata S., Tamura M., Kawaguchi T., Abe K., Sugihara K., Kato T., Nishiuchi T., Wakana S., Ikawa M. and Asano M. New insights on the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB Journal 2017, 31: 2252-2266. (doi:10.1096/fj.201600642R)

Kitazawa M., Tamura M., Kaneko-Ishino T. and Ishino F. Severe damage to the placental fetal capillary network causes mid to late fetal lethality and reduction of placental size in Peg11/Rtl1 KO mice. Genes to Cells 2017, 22: 174-188. (doi: 10.1111/gtc.12465)

Kataoka T., Tamura M., Amano T., Maeno A., Wakana S. and Shiroishi T. Genetic dissection of trabecular bone formation with the B6-MSM consomic mouse strains. G3: Genes, Genomes, Genetics 2017, 7: 3449-3457. (doi.org/10.1534/g3.117.300213)

Meehan TF., Conte N., West DB., Jacobsen JO, Mason J., Warren J., Chen C-K., Tudose I., Relac M., Matthews P., Karp N., Santos L., Fiegel T., Ring N., Westerberg H., Greenaway S., Sneddon D., Morgan H., Codner GF., Stewart ME, Brown J, Horner N., The International Mouse Phenotyping Consortium, Haendel M., Washington N., Mungall CJ., Reynolds CL., Gallegos J., Gailus-Durner V., Sorg T., Pavlovic G., Bower LB., Moore M., Morse I., Gao X., Tocchini-Valentini GP., Obata Y., Cho SY., Seong JK., Seavitt J., Beaudet AL., Dickinson ME., Herault Y., Wurst W., Hrabé de Angelis M., Lloyd KCK., Flenniken AM., Nutter LMJ., Newbigging S., McKerlie C., Justice MJ., Murray SA, Svenson KL., Braun RE., White JK., Bradley A., Flicek P., Wells S., Skarnes WC., Adams DJ., Parkinson H., Mallon AM., Brown SDM., Smedley D. Disease Model Discovery from 3,328 Gene Knockouts by The International Mouse Phenotyping Consortium. Nature Genetics 2017, 49: 1231-1238. (doi: 10.1038/ng.3901)

Bowl MR., Simon MM., Ingham NJ., Greenaway S., Santos L., Cater H., Taylor S., Mason J., Kurbatova N., Pearson S., Bower LR., Clary DA., Meziane H., Reilly P., Minowa O., Kelsey L., The International Mouse Phenotyping Consortium, Tocchini-Valentini GP., Gao X., Bradley A., Skarnes WC., Moore M., Beaudet AL., Justice MJ., Seavitt J., Dickinson ME., Wurst W., Hrabé de Angelis M., Herault Y., Wakana S., Nutter LMJ., Flenniken AM., McKerlie C., Murray SA., Svenson KL., Braun RE., West DB., Lloyd KCK., Adams DJ., White J., Karp N., Flicek P., Smedley D., Meehan TF., Parkinson HE., Teboul LM., Wells S., Steel KP., Mallon AM., Brown SDM. A large-scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nature Communications 2017, 8: 886. (doi: 10.1038/s41467-017-00595-4)

Karp NA., Mason J., Beaudet AL., Benjamini Y., Bower L., Braun RE., Brown SDM., Chesler EJ., Dickinson ME., Flenniken AM., Fuchs H., Gao X., Guo S., Greenaway S., Heller R., Herault Y., Hrabé de Angelis M., Justice MJ., Kurbatova N., Lelliott CJ., Lloyd KCK., Mallon AM., Mank JE., Masuya H., McKerlie C., Meehan TF., Mott RF., Murray SA., Parkinson H., Ramirez-Solis R., Santos L., Seavitt JR., Smedley D., Sorg T., Speak AO., Steel KP., Svenson KL., The International Mouse Phenotyping Consortium, Wakana S., West D., Wells S., Westerberg H., Yaacoby S. and White JK. Prevalence of sexual dimorphism in mammalian phenotypic traits. Nature Communications 2017, 8: 15475. (doi: 10.1038/ncomms15475)

Furuse T., Miyake K., Kohda T., Kaneda H., Hirasawa T., Yamada I., Kushida T.,, Kashimura M., Kobayashi K., Ishino F., Kubota T. and Wakana S. Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny. Genes & Nutrition 2017, 12: 1. (doi: 10.1186/s12263-016-0550-2)

Hirose M., Hasegawa A., Mochida K., Matoba S., Hatanaka Y., Inoue K., Goto T., Kaneda H., Yamada I., Furuse T., Abe K., Uenoyama Y., Tsukamura H., Wakana S., Honda A. and Ogura A. CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene. Scientific Reports 2017, 7: 42476. (doi: 10.1038/srep42476)

Okumura K., Saito M., Yoshizawa Y., Munakata H., Isogai E., Miura I., Wakana S., Yamaguchi M., Shitara H., Taya C., Karaplis AC., Kominami R. and Wakabayashi Y. The parathyroid hormone regulates skin tumour susceptibility in mice. Scientific Reports 2017, 7: 11208. (doi: 10.1038/s41598-017-11561-x)

Ohnishi T., Miura I., Ohba H., Shimamoto C., Iwayama Y., Wakana S. and Yoshikawa T. A spontaneous and novel Pax3 mutant mouse that models Waardenburg syndrome and neural tube defects. Gene 2017, 607: 16-22. (doi: 10.1016/j.gene.2016.12.037)

2016

Dickinson ME., Flenniken AM., Ji X., Teboul L., Wong MD., White JK., Meehan TF., Weninger WJ., Westerberg H., Adissu H., Baker CN., Bower L., Brown JM., Caddle LB., Chiani F., Clary D., Cleak J., Daly MJ., Denegre JM., Doe B., Edie SM., Fuchs H., Gailus-Durner V., Galli A., Gambadaro A., Gallegos J., Guo S., Horner NR., Hsu Cw., Johnson SJ., Kalaga S., Keith LC., Lanoue L., Lawson TN., Lek M., Mark M., Marschall S., Mason J., McElwee ML., Newbigging S., Nutter LMJ., Peterson KA., Ramirez-Solis R., Rowland DJ., Ryder E., Samocha KE., Seavitt JR., Selloum M., Szoke-Kovacs Z., Tamura M., Trainor AG., Tudose I., Wakana S., Warren J., Wendling O., West DB., Wong L., Yoshiki A., The International Mouse Phenotyping Consortium, MacArthur DG., Tocchini-Valentini GP., Gao X., Flicek P., Justice M., Parkinson HE., Moore M., Wells S., Braun RE., Svenson K., Hrabé de Angelis M., Herault Y., Mohun T., Mallon AM., Henkelman RM., Brown SD., Adams D., Lloyd KCK., McKerlie C., Beaudet AL., Bucan M. and Murray SA. High-throughput discovery of novel developmental phenotypes. Nature 2016, 537: 508-514. (doi:10.1038/nature19356)

Funato H., Miyoshi C., Fujiyama T., Kanda T., Sato M., Wang Z., Ma J., Nakane S., Tomita J., Ikkyu A., Kakizaki M., Hotta-Hirashima N., Kanno S., Komiya H., Asano F., Honda T., Kim SJ., Harano K., Muramoto H., Yonezawa T., Mizuno S., Miyazaki S., Connor L., Kumar V., Miura I., Suzuki T., Watanabe A., Abe M., Sugiyama F., Takahashi S., Sakimura K., Hayashi Y., Liu Q., Kume K., Wakana S., Takahashi1 JS. and Yanagisawa M. Forward-genetics analysis of sleep in randomly mutagenized mice. Nature 2016, 539: 378-383. (doi:10.1038/nature20142)

Yoshizaki K., Furuse T., Kimura R., Tucci V., Kaneda H., Wakana S. and Osumi N. Paternal Aging Affects Behavior in Pax6 Mutant Mice: A Gene/Environment Interaction in Understanding Neurodevelopmental Disorders. PLoS ONE 2016, 11: e0166665. (doi.org/10.1371/journal.pone.0166665)

Ohba K., Takeda K., Furuse T., Suzuki T., Wakana S., Suzuki T., Yamamoto H. and Shibahara S. Microphthalmia-associated transcription factor ensures the elongation of axons and dendrites in the mouse frontal cortex. Genes to Cells 2016, 21:1365-1379. (doi: 10.1111/gtc.12450)

Liu Y., Maekawa T., Yoshida K., Furuse T., Kaneda H., Wakana S. and Ishii S. ATF7 ablation prevents diet-induced obesity and insulin resistance. Biochemical and Biophysical Research Communications 2016, 478: 696-702. (doi: 10.1016/j.bbrc.2016.08.009)

Yoshikawa F., Sato Y., Tohyama K., Akagi T., Furuse T., Sadakata T., Tanaka M., Shinoda Y., Hashikawa T., Itohara S., Sano Y., Ghandour MS., Wakana S. and Furuichi T. Mammalian-Specific central myelin protein Opalin is redundant for normal myelination: structural and behavioral assessments. PLoS One 2016, 11: e0166732. (doi: 10.1371/journal.pone.0166732)

Yasuda T., Fukada T., Nishida K., Nakayama M., Matsuda M., Miura I., Dainichi T., Fukuda S., Kabashima K., Nakaoka S., Bin BH., Kubo M., Ohno H., Hasegawa T., Ohara O., Koseki H., Wakana S. and Yoshida H. Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis. Journal of Clinical Investigation 2016, 126: 2064-76. (doi: 10.1172/JCI82887)

Hossain MS., Asano F., Fujiyama T., Miyoshi C., Sato M., Ikkyu A., Kanno S., Hotta N., Kakizaki M., Honda T., Kim SJ., Komiya H., Miura I., Suzuki T., Kobayashi K., Kaneda H., Kumar V., Takahashi JS., Wakana S., Funato H. and Yanagisawa M. Identification of mutations through dominant screening for obesity using C57BL/6 substrains. Scientific Reports 2016, 6: 32453. (doi: 10.1038/srep32453)

Xie Z., Kitamoto A., Tamura M., Shiroishi T. and Gillies D. High-throughput mouse phenotyping using non-rigid registration and robust principal component analysis. Proceedings of SPIE 9784, Biomedical Imaging 2016, Image Processing, 978415, e1-e8. (doi:10.1117/12.2217155)

2015

Tamura M. and Shiroishi T. GSDM family genes meet autophagy. Biochemical Journal 2015, 469: e5-e7. (doi: 10.1042/BJ20150558)

Xie Z., Liang X., Guo L., Kitamoto A., Tamura M., Shiroishi T. and Gillies D. An automatic classification framework for ventricular septal defects: a pilot study on high-throughput mouse embryo cardiac phenotyping. Journal of Medical Imaging 2015, 2: 041003. (doi: 10.1117/1.JMI.2.4.041003)

Liang X., Xie Z., Tamura M., Shiroishi T., Kitamoto A. Towards high-throughput mouse embryonic phenotyping: a novel approach to classifying ventricular septal defects. Proceedings of SPIE 9413, Medical Imaging 2015: Image Processing, 94131V, 2015, 66: 1-8. (doi: 10.1117/12.2081148)

Irie M., Yoshikawa M., Ono R., Iwafune H., Furuse T., Yamada I., Wakana S., Yamashita Y., Abe T., Ishino F. and Kaneko-Ishino T. Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians. PLoS Genetics 2015, 11: e1005521. (doi: 10.1371/journal.pgen.1005521)

Hirawatari K., Hanzawa N., Miura I., Wakana S. and Gotoh H. A Cascade of epistatic interactions regulating teratozoospermia in mice. Mammalian Genome 2015, 26: 248-56. (doi: 10.1007/s00335-015-9566-y)

Uchimura A., Higuchi M., Minakuchi Y., Ohno M., Toyoda A., Fujiyama A., Miura I., Wakana S., Nishino J. and Yagi T. Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice. Genome Research 2015, 25: 1125-34. doi: 10.1101/gr.186148.114.

Kamimura D., Katsunuma K., Arima Y., Atsumi T., Jiang JJ., Bando H., Meng J., Sabharwal L., Stofkova A., Nishikawa N., Suzuki H., Ogura H., Ueda N., Tsuruoka M., Harada M., Kobayashi J., Hasegawa T., Yoshida H., Koseki H., Miura I., Wakana S., Nishida K., Kitamura H., Fukada T., Hirano T. and Murakami M. KDEL receptor 1 regulates T-cell homeostasis via PP1 that is a key phosphatase for ISR. Nature Communications 2015, 6: 7474. (doi: 10.1038/ncomms8474)

Konno D., Kasukawa T., Hashimoto K., Itoh T., Suetsugu T., Miura I., Wakana S., Carninci P. and Matsuzaki F. STAP cells are derived from ES cells. Nature 2015, 525: E4-5. (doi: 10.1038/nature15366)

2014

Tamura M., Amano T. and Shiroishi T. The Hand2 gene dosage effect in developmental defects and human congenital disorders. Current Topics in Developmental Biology 2014, 110: 129-152. (doi: 10.1016/B978-0-12-405943-6.00003-8)

Nabeshima Y., Washida M., Tamura M., Yurugi K., Ohnishi M., Maeno A., St-Arnaud S., Shiroishi T., Razzaque MS., Imura A. and Nabeshima Y. Calpain 1 inhibitor, BDA-410 restores a-klotho deficient phenotypes resembling to human aging related syndromes. Scientific Reports 2014, 4: 5847. (doi:10.1038/srep05847)

Kono H., Tamura M.,, Osada N., Suzuki H., Abe K., Moriwaki K., Ohta K. and Shiroishi T. Prdm9 polymorphism unveils mouse evolutionary tracks. DNA Research 2014 21: 315-326. (doi: 10.1093/dnares/dst059)

Liang X., Xie Z., Kitamoto A., Tamura M., Shiroishi T. and Kotagiri R. A novel atlas-based approach to the detection of mouse embryo ventricular septal defects. Medical image computing and computer-assisted intervention 2014, 44-45.

Naruse M., Ono R., Irie M., Nakamura K., Furuse T., Hino T., Oda K., Kashimura M., Yamada I., Wakana S., Yokoyama M., Ishino F. and Kaneko-Ishino T. Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition. Development 2014, 141: 4763-4771. (doi: 10.1242/dev.114520)

Arime Y., Fukumura R., Miura I., Mekada K., Yoshiki A., Wakana S., Gondo Y. and Akiyama K. Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice. Behavioral and Brain Functions 2014, 10: 45. (doi: 10.1186/1744-9081-10-45)

Okumura K., Saito M., Isogai E., Miura I., Wakana S., Kominami R. and Wakabayashi Y. Congenic mapping and allele-specific alteration analysis of Stmm1 locus conferring resistance to early-stage chemically induced skin papillomas. PLoS One 2014, 9: e97201. (doi: 10.1371/journal.pone.0097201)

Saito M., Okumura K., Miura I., Wakana S., Kominami R. and Wakabayashi Y. Identification of Stmm3 locus conferring resistance to late-stage chemically induced skin papillomas on mouse chromosome 4 by congenic mapping and allele-specific alteration analysis. Experimental Animals 2014, 63: 339-348. (doi: 10.1538/expanim.63.339)

2013

Tamura M., Hosoya M., Fujita M., Iida T., Amano T., Maeno A., Kataoka T., Otsuka T., Tanaka S, Tomizawa S. and Shiroishi T. Over-dosage of Hand2 causes limb and heart defects in human chromosomal disorder, partial trisomy distal 4q. Human Molecular Genetics 2013, 22: 2471-2481. (doi: 10.1093/hmg/ddt099)

Tanaka S., Mizushina Y., Kato Y., Tamura M. and Shiroishi T. Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome. G3: Genes, Genomes, Genetics 2013, 3: 1843-1850. (doi: 10.1534/g3.113.007393)

Roy S., Liang X., Kitamoto A., Tamura M., Shiroishi T. and Brown MS. Phenotype detection in morphological mutant mice using deformation features. Medical image computing and computer-assisted intervention 2013, 16: 437-444.

Suzuki T., Furuse T., Yamada I., Motegi H., Kozawa Y., Masuya H., Wakana S. Pheno-Pub: a total support system for the publication of mouse phenotypic data on the web. Mammalian Genome 2013, 24 (11-12): 473-83. (doi: 10.1007/s00335-013-9482-y)

Umemori J., Takao K., Koshimizu H., Hattori S., Furuse T., Wakana S. and Miyakawa T. ENU-mutagenesis mice with a non-synonymous mutation in Grin1 exhibit abnormal anxiety-like behaviors, impaired fear memory, and decreased acoustic startle response. BMC Research Notes 2013, 6: 203. doi: 10.1186/1756-0500-6-203.

Toki H., Inoue M., Motegi H., Minowa O., Kanda H., Yamamoto N., Ikeda A., Karashima Y., Matsui J., Kaneda H., Miura I., Suzuki T., Wakana S., Masuya H., Gondo Y., Shiroishi T., Akiyama T., Yao R. and Noda T. Novel mouse model for Gardner syndrome generated by a large-scale N-ethyl-N-nitrosourea mutagenesis program. Cancer Science 2013, 104: 937-944. (doi: 10.1111/cas.12161)