Old topics
| 2018/03/22 | Phenotyping progress was updated. |
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| 2017/12/11 | Comprehensive mouse phenotyping data of the late-onset screen in IMPC pipeline were published in the following site. http://mouseclinic.brc.riken.jp/control-aged_mice/ |
| 2017/10/27 | As a part of the results of IMPC project (the Japan Mouse Clinic is participating), we have performed the high-throughput hearing phenotyping in the IMPC KO mice, analyzed for up to 3006 knockout lines, and we detect known hearing loss genes, but the vast majority, 52. The results have been published in Nature Communications (26th June 2017) and has implications for understanding the physiological complexity of the auditory system in human auditory function. https://www.nature.com/articles/s41467-017-00595-4 https://www.nature.com/articles/s41467-017-00595-4.pdf |
| 2017/08/25 | Phenotyping progress was updated. |
| 2017/07/11 |
As a part of the results of IMPC project (the Japan Mouse Clinic participates in), we have performed the high-throughput phenotyping in the wildtype and the mutant mice, analyzed for up to 234 traits of the representing 2,186 knockout lines, and we found a large proportion of mammalian traits in both types were influenced by sex. The results have been published in Nature Communications (26th June 2017) and has implications for interpreting disease phenotypes in animal models and humans. https://www.nature.com/articles/ncomms15475 https://www.nature.com/articles/ncomms15475.pdf |
| 2017/07/03 | The schedule of the phenotyping pipeline 1 has been slightly changed. |
| 2017/04/24 |
Researchers from the Global Research Cluster in RIKEN have developed a potential mouse model for the genetic disorder known as an NGLY1 deficiency. Published in the journal PLOS Genetics, the study describes how a complete knockout of the Ngly1 gene in mice leads to death just before birth, which can be partially rescued by a second knockout of another gene called Engase. This is a collaborative work of RIKEN scientists including Drs. Suzuki, Fujihira, and Taniguchi of the Global Research Cluster and Drs. Tamura and Wakana of the Japan Mouse Clinic Team. http://www.riken.jp/en/pr/press/2017/20170422_1/ http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006696 |
| 2017/02/17 |
The collaborative research team consisting of Kyoto University (Dr. Naruse C. and Prof. Asano M.), Osaka University (Prof. Ikawa M.) and The Japan Mouse Clinic found that the demethylase activity of Jmjd3, which tightly regulates the expression of Hox cluster genes, is critical for the vertebra and rib development in the mouse. This result was published in the "FASEB Journal." http://doi.org/10.1096/fj.201600642R |
| 2016/11/22 |
Phenotyping progress was updated.
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| 2016/11/18 |
Prof. Osumi and Dr. Yoshizaki of Tohoku University and The Japan Mouse Clinic team indicate that mice with a single genetic risk factor can develop different phenotypes with behavioral abnormalities depending on the paternal age. Our study advocates for serious considerations on the role of paternal aging in breeding strategies for animal studies. This result is published in the online issue of PLOS ONE on November 18th. http://dx.doi.org/10.1371/journal.pone.0166665 |
| 2016/11/07 | University of Tsukuba WPI-IIIS group (Drs. Funato and Yanagisawa) and The Japan Mouse Clinic team use genetic screening approach ( ENU mutagenesis ) for identify mutations that affect sleep/wakefulness in mice. This landmark paper was published in the issue of Nature on November 17th. http://www.nature.com/nature/journal/v539/n7629/pdf/nature20142.pdf |
| 2016/10/25 | The phenotyping pipeline 1 on the Japan Mouse Clinic has been reestablished. |
| 2016/09/20 |
The International Mouse Phenotyping Consortium (IMPC) identified 410 genes that are essential to life in the mouse through the comprehensive phenotyping of 1751 KO mouse lines. The results have been published in Nature (22nd September 2016) and will provide invaluable data set to investigate gene function and contribute to conquer human intractable diseases. http://www.nature.com/nature/journal/v537/n7621/pdf/nature19356.pdf |
| 2016/08/22 | The Japan Mouse Clinic has planed the late-onset phenotyping pipeline which is performed on 49 wks to 56 wks. |
| 2016/05/30 |
The Fifth RIKEN BRC-Nanjing University MARC Mouse Resource Workshop will be co-organized by RIKEN
BioResource Center and Nanjing University Model Animal Research Center. In the course, the SHIRPA workshop will be operated by the Japan Mouse Clinic. Date: July 25 - 27, 2016 Place: RIKEN BioResource Center Registraion Fee: Free Official Language: English Online Registration: http://rtcweb.rtc.riken.jp/English/meeting/SummerCourse/index.html |
| 2016/04/11 | The Modified SHIRPA Technical Training Course was launched in the RIKEN BioResource Center. |
| 2016/03/01 | Phenotyping progress was updated. |
| 2016/01/08 |
The technical training course of the RIKEN Modified
SHIRPA was launched in the RIKEN BioResource Center.
Phenotype criteria with movies and images of Combined Modified SHIRPA and Dysmorphology (CSD) have been added in the RIKEN Modified SHIRPA homepage. |
| 2015/11/16 | Website and online payment will stop services on the following period,
due to regular maintenance. Date : Nov 23 2015 (JST) For this reason, during this time, you can't access our website. We apologize for any inconvenience this may cause and ask for your understanding. |
| 2015/11/13 | The International Mouse Phenotyping Consortium Symposium has been finished. Thank you for your cooperation!! |
| 2015/11/06 | Phenotyping progress was updated. |
| 2015/10/21 | Phenotype criteria with movies and images have been added in the RIKEN Modified SHIRPA homepage. |
| 2015/09/09 | Phenotypic information of C57BL/6NCrl strain has been released at "Strain Viewer" in the page "Pheno-pub". |
| 2015/09/04 |
IMPC International Symposium in Yokohama will be held on 12th November as a
satellite symposium of IMGC2015. The focus of the symposium will be the
promotion of dissemination of the IMPC mouse lines, the importance of mouse
phenotyping, and collaboration with clinical & drug discovery scientists. The place is the Yokohama Port Opening Memorial Hall. Please refer to HP & pdf file. Contact to: impc2015@ml.brc.riken.jp |
| 2015/09/01 | The paper entitled "Principles and application of LIMS in mouse clinics." is published on Mammalian genome with IMPC mouse clinic group. |
| 2015/06/01 | The paper entitled "Applying the ARRIVE Guidelines to an In Vivo Database" is published on Plos Biology journal. |
| 2015/05/25 | Top page of JMC was improved for easy access to our projects. |
| 2015/05/13 | Search function of development and phenotype information of IMPC knockout mouse strains is added in the “Activity for IMPC” page. |
| 2015/03/31 | Phenotyping progress was updated. |
| 2014/07/17 | Measurement parameters in procedures of hematology, clinical blood chemistry and adipocytokines were changed. |
| 2014/06/26 |
The 3rd International Short Summer Course of the Mouse co-organized by RIKEN
BioResource Center and Nanjing University Model Animal Research Center. In the course, the SHIRPA workshop will be operated by the Japan Mouse Clinic. Date: July 28 - 30, 2014 Place: RIKEN BioResource Center Registraion Fee: Free Official Language: English Online Registration: http://rtcweb.rtc.riken.jp/English/meeting/SummerCourse/index.html |
| 2014/06/06 | A full workflow video of Combined Modified SHIRPA and Dysmorphology (CSD) and a latest list of test items have been added in the RIKEN Modified SHIRPA homepage. |
| 2014/06/06 | IMPC SOPs in Japan Mouse Clinic were released in the page "Activity for IMPC". |
| 2014/06/05 | Phenotypic information of several mutant strains have been released at "Genotype viewer" and "Strain Viewer" in the page "Pheno-pub". |
| 2014/03/31 | Phenotyping progress was updated. |
| 2014/01/23 | Phenotyping progress was updated. |
| 2013/11/13 | The paper entitled “Pheno-Pub: a total support system for the publication of mouse phenotypic data on the web”, is published in Mammalian Genome Vol.24:473-83 (2013). |
| 2013/07/09 | New version of Genotype Viewer in "pheno-Pub", a total support application system for publication of mouse phenotypic data on the Web, was released in the homepage. Measured data and their statistics of mutants on the Genotype Viewer website are downloadable from the top page. |
| 2013/06/13 |
The 2nd International Short Summer Course of the Mouse co-organized by RIKEN
BioResource Center and Nanjing University Model Animal Research Center.
In the course, the SHIRPA workshop will be operated by the Japan Mouse Clinic. Date: July 29 - 31, 2013 Place: Model Animal Research Centre, Nanjing University Registraion Fee: Free Official Language: English Online Registration: http://summer.app.nicemice.cn/en/join.php or contact: Dr. PAN Dejing, Model Animal Research Centre Nanjing University Email:pandj@nicemice.cn, pandj@nbri-nju.com |
| 2013/02/07 | We set up the application download site of "Pheno-Pub", a total support system for publication of mouse phenotypic data on the Web. |
| 2012/12/25 | The Pipeline 2 is now under reconstruction. Clients are unable to acceptance to behavior analysis. |
| 2012/09/21 | Phenotype criteria with movies and images have been added in the RIKEN Modified SHIRPA homepage. |
| 2012/07/30 | IMPC Symposium in Tokyo will be informed on the website. |
| 2012/06/12 | The technical training course of the RIKEN Modified SHIRPA was launched in the RIKEN BioResource Center. |
| 2012/03/14 | "RIKEN Modified SHIRPA" homepage was relaunched. |
| 2012/02/24 | The JMC phenotyping pipelines were modified by change of some examinations constituting them. |
| 2011/11/01 | Setup the link to the RIKEN Modified SHIRPA homepage. |
| 2011/10/01 | IMPC(International Mouse Phenotype Consortium) is to be launched on 29th September 2011. RIKEN BRC is an official member of IMPC. |
| 2011/08/25 | "Japan Mouse Clinic" homepage was relaunched with its new browsing system. Phenotypic information of a few strains has been newly added in new "Pheno-pub" homepage. |
| 2011/06/08 | The RIKEN Modified SHIRPA home page has been established for supporting of its technical learning. |
| 2011/02/24 | Phenotypic information of five mutant strains has been added in "Phenotypic viewer of the difference between genotypes" in the "Pheno-pub" page. |
| 2010/12/13 | Phenotypic information of several mutant strains have been released at "Phenotypic viewer of the difference between genotypes" in the "Pheno-pub" page. |
| 2010/06/21 | A link to Mouse husbandry SDOP in Japan Mouse Clinic has been posted. |
| 2009/10/28 | Updated phenotypic information in "phenotypic viewer of the differences among strains" in Pheno-Pub system. |
| 2009/10/25 | Introduction to "Japan Mouse Clinic" was reported in the following article. Wakana S., Suzuki T., Furuse T., Kobayashi K., Miura I., Kaneda H., Yamada I., Motegi H., Toki H., Inoue M., Minowa O., Noda T., Waki K., Tanaka N., Masuya H., and Obata Y. Introduction to the Japan Mouse Clinic at the RIKEN BioResource Center. Exp Anim., 58:443-450(2009) We have developed a new stable production system using C57BL/6J cryopreserved sperm. Taguma, K., Nakamura, C., Ozaki, A., Suzuki, C., Hachisu, A., Kobayashi, K., Mochida, K., Ogura, A., Kaneda, H., and Wakana, S. A Practical Novel Method for Ensuring Stable Capacitation of Spermatozoa from Cryopreserved C57BL/6J Sperm Suspension. Exp. Anim. 58: 395-401.(2009) |
| 2009/06/09 | Links to comparative protocol database, SDOPDB, have been posted. |
| 2009/05/13 | We have released "Pheno-pub" system of a website to display the phenotypic data of various mice resources examined in "Japan mouse clinic". |
| 2008/11/01 | "SOPs" page has been posted. |
| 2008/08/20 | "Japan Mouse Clinic" is available to investigators for phenotypic analyses of your mice. |
