Mouse Phenotype Analysis Division develops "Mouse Clinic" which is a phenotype analysis platform for genetically modified mice that systematically examines more than 700 items, aiming to understand the human diseases and elucidate gene functions. The division participates in the International Mouse Phenotyping Consortium (IMPC), publishes the results of the phenotype analyses, and develops new technologies on phenotyping analyses.
Mission
- Development of systematic and comprehensive phenotyping platform for mice
- International contribution through participation in the IMPC
- Provision of international standardized phenotyping methods to the domestic research community
- Development of new phenotyping methods
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Japan Mouse Clinic is one of institutional members of IMPC (International Mouse Phenotyping Consortium). |
| Enter the page "Activity for IMPC" to search phenotype and development information of IMPC Knockout mouse strains. | |
What's news
| 2023/12/26 | A review paper on next-generation electron microscopy techniques has been published in the Journal of Molecular Cell Biology. The paper, in which Dr. Tamura participated, is the result of joint research with RIKEN BDR, RIKEN IMS, Kyoto University and JEOL. Son R. et al., Journal of Molecular Cell Biology 2023. mjad081 |
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| 2023/08/31 | A paper demonstrating that heterozygous loss-of-function mutations in the DHX9 gene are associated with neurodevelopmental disorders has been published in the European Journal of Medical Genetics. The paper is the result of collaborative research with Keio University, Niigata University and the National Institute of Genetics. Yamada M.et al., European Journal of Medical Genetics 2023. 66: 104804. |
| 2023/04/01 | As a new key technology development program, the Mouse Phenotyping Analysis Division was established in April 2023 by reorganizing the Technology and Development Team for Mouse Phenotype Analysis. |
| 2023/04/01 | Automated hematology analyzer was updated to XN-1000V (sysmex).In clinical biochemical test, LD and ALP measurement methods were replaced by IFCC method for JSCC method. |
| 2023/02/16 | "Interview with women in research positions" has received RIKEN Diversity Award 2022 for the diversity efforts. |
| 2023/01/31 | A review article on ECG from the IMPC project, in which the Mouse Phenotyping Technology Office participates, has been published in Mammalian Genome. Oestereicher MA. et al., Mammalian Genome 2023. 34:180-199. |
| 2023/01/23 | A paper on tertiary lymphoid tissue (TLT) that may be involved in chronic kidney disease (CKD) and end-stage renal disease (ESRD) has been published in Nephrology Dialysis Transplantation. Dr. Tamura participated in the imaging analysis of this paper. Sato Y. et al., Nephrology Dialysis and Transplantation 2023. 38: 26-33. |
| 2022/12/08 | A research paper on high-resolution kidney morphometry using X-ray microscopy has been published in the journal Microscopy. This research is the result of collaboration between RIKEN Engineering Project, Kyoto University, and Rigaku Corporation. Kunishima N., et al., Microscopy 2022. 71:315-323. |
| 2022/10/28 | A research paper on the function of the Exocyst Complex Component 3-like 2 gene during heart formation has been published in Life. This paper is the result of collaborative research with Shiga University of Medical Science, University of Tsukuba, Kobe Gakuin University and Keio University. Watanabe C. et al., Life 2022. 12:1730. |
| 2022/10/21 | A research paper on the function of the Scl39a13/ZIP13 gene in cardiovascular homeostasis has been published in PLOS ONE. This paper is the result of a collaborative research with Tokushima Bunri University, Nagahama Institute of Bio-Science and Technology, RIKEN IMS, Kazusa DNA Research Institute and Maria Hospital in Portugal. Hara T. et al., PLOS ONE 2022. 17: e0276452. |
| 2022/05/20 | Dr. Miura's research paper, "Characterization of single nucleotide polymorphisms for a forward genetics approach using genetic crosses in C57BL/6 and BALB/c substrains of mice" was published in Experimental Animals. https://www.jstage.jst.go.jp/article/expanim/71/2/71_21-0181/_article/-char/en |
