Genotype Viewer

Analysis Group	Condition; Aged mice (B6/NJcl)
Analysis Group Description	Phenotypic differences of C57BL/6NJcl strain between early and late age have been analyzed in this analysis group. Test mice were produced by the natural mating and reared under the JMC standard housing conditions.

Procedure	Clinical Blood Chemistry Clinical biochemical test v2
Pipeline	IMPC_adult_v2-LaterOnset	Screen Age (week)	16-56w

Strain	Associated Gene(s)	Housing SOP(s) and SDOP(s)
	C57BL/6NJcl		Mouse husbandry (RIKEN BRC)

Strain	C57BL/6NJcl	Strain description
Associated Gene(s)		This strain was provided from CLEA Japan and has been maintained by natural mating for two generations.
Housing SOP(s) and SDOP(s)	Mouse husbandry (RIKEN BRC)
Tested Day (Age)	2015/11/25 - 2016/08/31 (16.5 - 56.93)

Strain	Condition 1	Pipeline(s)	Tested Day (Age)
Strain	Condition 1	IMPC_adult_v2-LaterOnset	Tested Day (Age)
C57BL/6NJcl	Late	♀: 11 ♂: 9	2015/11/25 - 2016/08/31 (16.5 - 56.93)
C57BL/6NJcl	Early	♀: 14 ♂: 12	2015/11/25 - 2016/08/31 (16.5 - 56.93)

Parameter	Difference	Supplement
Albumin (ALB:g/L)	S
Alkaline phosphatase (ALP)	NS
Alanine aminotransferase (ALT)	NS
Alpha-amylase (AMY)	S
Aspartate aminotransferase (AST)	NS
Calcium (Ca)	S
Creatine kinase (CPK)	NS
Creatinine (CRE)	S
Iron (Fe:mg/dL)	S
Glucose (Glu)	NS
Glycosilated hemoglobin A1c (HbA1c)	NS
HDL-cholesterol (HDL-C)	NS
Phosphate (IP)	S
Lactate dehydrogenase (LDH)	NS
LDL-cholesterol (LDL-C)	S
Total bilirubin (T-BIL)	S
Total cholesterol (T-CHO)	S
Triglycerides (TG)	NS
Total protein (TP:g/L)	S
Uric acid (UA:umol/L)	NS
Urea (UN)	S

comment
Urea(UN) was increased in 56-week-old mice (Late) relative to 16-week-old mice (Early).Total bilirubin (T-BIL) and Phosphate (IP) were decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early).Albumin(ALB) and Alpha-amylase(AMY) and Calcium(Ca) and Total protein(TP) and Total cholesterol(T-CHO) were increased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only male. Creatinine(CRE) was decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only male. Iron(Fe) and LDL-cholesterol(LDL-C) were decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only female. LDL-cholesterol(LDL-C) was increased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only male.

comment

Urea(UN) was increased in 56-week-old mice (Late) relative to 16-week-old mice (Early).Total bilirubin (T-BIL) and Phosphate (IP) were decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early).Albumin(ALB) and Alpha-amylase(AMY) and Calcium(Ca) and Total protein(TP) and Total cholesterol(T-CHO) were increased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only male. Creatinine(CRE) was decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only male. Iron(Fe) and LDL-cholesterol(LDL-C) were decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only female. LDL-cholesterol(LDL-C) was increased in 56-week-old mice (Late) relative to 16-week-old mice (Early) in only male.