Procedure Clinical Blood Chemistry Clinical biochemical test v2
Pipeline IMPC_adult_v2-LaterOnset Screen Age (week) 16-56w
Parameter LDL-cholesterol (LDL-C)
Strain Condition 1 Pipeline(s) Tested Day
(Age)
IMPC_adult_v2-LaterOnset
C57BL/6NJcl Late ♀: 11  ♂: 8 2015/11/25 - 2016/08/31
(16.5 - 56.93)
Early ♀: 14  ♂: 12
Raw Data

Bartlett test result
Factor df Bartlett's K2 p
condition1 1 1.445653 0.2292268
sex 1 0.2500877 0.6170133

Summary statistics
Factor mean median SD SEM N
condition1 - sex
Early(16w) - Female 7.68 7.49 2.22 0.59 14
Early(16w) - Male 3.4 3.25 1.37 0.39 12
Late(56w) - Female 5.27 5.16 1.49 0.45 11
Late(56w) - Male 6.36 7.04 2.86 1.01 8

ANOVA result
Signif. codes ***: <0.001
**: <0.010
*: <0.050
†: <0.100
Factor df Sum Sq. F value Pr(>F) Signif.
condition1 1 0.035 0.0087 0.926327
sex 1 45.937 11.5148 0.001542 **
condition1:sex 1 77.970 19.5446 7.06e-05 ***
Residuals 41 163.563

Tukey multiple comparisons of means
Factor: sex
Level Difference Lower Upper Adjusted p
Male - Female -2.03 -3.24 -0.822 0.00155

Factor: condition1:sex
Level Difference Lower Upper Adjusted p
Late(56w):Female - Early(16w):Female -2.41 -4.565 -0.256 2.31e-02
Early(16w):Male - Early(16w):Female -4.28 -6.383 -2.176 1.53e-05
Late(56w):Male - Early(16w):Female -1.31 -3.684 1.056 4.56e-01
Early(16w):Male - Late(56w):Female -1.87 -4.101 0.363 1.29e-01
Late(56w):Male - Late(56w):Female 1.10 -1.389 3.582 6.42e-01
Late(56w):Male - Early(16w):Male 2.97 0.524 5.406 1.18e-02



FM_02_U_barchart.png

comment
LDL-C was significantly decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early) (p<0.05) in only female.
LDL-C was significantly increased in 56-week-old mice (Late) relative to 16-week-old mice (Early) (p<0.05) in only male.