Procedure | Clinical Blood Chemistry Clinical biochemical test v2 | ||
---|---|---|---|
Pipeline | IMPC_adult_v2-LaterOnset | Screen Age (week) | 16-56w |
Parameter | LDL-cholesterol (LDL-C) |
Strain | Condition 1 | Pipeline(s) | Tested Day (Age) |
---|---|---|---|
IMPC_adult_v2-LaterOnset | |||
C57BL/6NJcl | Late | ♀: 11 ♂: 8 |
2015/11/25 - 2016/08/31 (16.5 - 56.93) |
Early | ♀: 14 ♂: 12 |
Factor | df | Bartlett's K2 | p |
---|---|---|---|
condition1 | 1 | 1.445653 | 0.2292268 |
sex | 1 | 0.2500877 | 0.6170133 |
Factor | mean | median | SD | SEM | N |
---|---|---|---|---|---|
condition1 - sex | |||||
Early(16w) - Female | 7.68 | 7.49 | 2.22 | 0.59 | 14 |
Early(16w) - Male | 3.4 | 3.25 | 1.37 | 0.39 | 12 |
Late(56w) - Female | 5.27 | 5.16 | 1.49 | 0.45 | 11 |
Late(56w) - Male | 6.36 | 7.04 | 2.86 | 1.01 | 8 |
Signif. codes ***: <0.001 **: <0.010 *: <0.050 : <0.100 |
||||||
Factor | df | Sum Sq. | F value | Pr(>F) | Signif. | |
---|---|---|---|---|---|---|
condition1 | 1 | 0.035 | 0.0087 | 0.926327 | ||
sex | 1 | 45.937 | 11.5148 | 0.001542 | ** | |
condition1:sex | 1 | 77.970 | 19.5446 | 7.06e-05 | *** | |
Residuals | 41 | 163.563 | ||||
Level | Difference | Lower | Upper | Adjusted p |
---|---|---|---|---|
Male - Female | -2.03 | -3.24 | -0.822 | 0.00155 |
Level | Difference | Lower | Upper | Adjusted p |
---|---|---|---|---|
Late(56w):Female - Early(16w):Female | -2.41 | -4.565 | -0.256 | 2.31e-02 |
Early(16w):Male - Early(16w):Female | -4.28 | -6.383 | -2.176 | 1.53e-05 |
Late(56w):Male - Early(16w):Female | -1.31 | -3.684 | 1.056 | 4.56e-01 |
Early(16w):Male - Late(56w):Female | -1.87 | -4.101 | 0.363 | 1.29e-01 |
Late(56w):Male - Late(56w):Female | 1.10 | -1.389 | 3.582 | 6.42e-01 |
Late(56w):Male - Early(16w):Male | 2.97 | 0.524 | 5.406 | 1.18e-02 |
comment |
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LDL-C was significantly decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early) (p<0.05) in only female. LDL-C was significantly increased in 56-week-old mice (Late) relative to 16-week-old mice (Early) (p<0.05) in only male. |