| Procedure | Grip Strength | ||
|---|---|---|---|
| Pipeline | IMPC_adult_v2-LaterOnset | Screen Age (week) | 9-49w |
| Parameter | Forelimb grip strength normalised against body weight | ||
| Strain | Condition 1 | Pipeline(s) | Tested Day (Age) |
|---|---|---|---|
| IMPC_adult_v2-LaterOnset | |||
| C57BL/6NJcl | Late | ♀: 11 ♂: 9 |
2015/10/06 - 2016/07/12 (9.36 - 49.93) |
| Early | ♀: 14 ♂: 13 |
| Factor | df | Bartlett's K2 | p |
|---|---|---|---|
| condition1 | 1 | 0.5492389 | 0.4586288 |
| sex | 1 | 1.980227 | 0.1593665 |
| Factor | mean | median | SD | SEM | N |
|---|---|---|---|---|---|
| condition1 - sex | |||||
| Early(9w) - Female | 3.15 | 3.01 | 0.75 | 0.2 | 14 |
| Early(9w) - Male | 2.86 | 2.34 | 1.1 | 0.31 | 13 |
| Late(49w) - Female | 2.4 | 2.36 | 0.75 | 0.23 | 11 |
| Late(49w) - Male | 1.62 | 1.37 | 0.64 | 0.21 | 9 |
| Signif. codes ***: <0.001 **: <0.010 *: <0.050 †: <0.100 |
||||||
| Factor | df | Sum Sq. | F value | Pr(>F) | Signif. | |
|---|---|---|---|---|---|---|
| condition1 | 1 | 10.9189 | 15.2578 | 0.0003267 | *** | |
| sex | 1 | 2.8938 | 4.0438 | 0.0506315 | † | |
| condition1:sex | 1 | 0.6712 | 0.9379 | 0.3382323 | ||
| Residuals | 43 | 30.7721 | ||||
| Level | Difference | Lower | Upper | Adjusted p |
|---|---|---|---|---|
| Late(49w) - Early(9w) | -0.96 | -1.46 | -0.456 | 0.000393 |
| comment |
|---|
| Forelimb grip strength normalised against body weight was significantly decreased in 49-week-old mice (Late) relative to 9-week-old mice (Early) (p<0.01). |