| Procedure | Grip Strength | ||
|---|---|---|---|
| Pipeline | IMPC_adult_v2-LaterOnset | Screen Age (week) | 9-49w |
| Parameter | Forelimb and hindlimb grip strength normalised against body weight | ||
| Strain | Condition 1 | Pipeline(s) | Tested Day (Age) |
|---|---|---|---|
| IMPC_adult_v2-LaterOnset | |||
| C57BL/6NJcl | Late | ♀: 11 ♂: 9 |
2015/10/06 - 2016/07/12 (9.36 - 49.93) |
| Early | ♀: 14 ♂: 13 |
| Factor | df | Bartlett's K2 | p |
|---|---|---|---|
| condition1 | 1 | 0.02781769 | 0.8675381 |
| sex | 1 | 0.5651424 | 0.4521957 |
| Factor | mean | median | SD | SEM | N |
|---|---|---|---|---|---|
| condition1 - sex | |||||
| Early(9w) - Female | 6.55 | 6.78 | 0.79 | 0.21 | 14 |
| Early(9w) - Male | 5.56 | 5.35 | 1.12 | 0.31 | 13 |
| Late(49w) - Female | 5.38 | 5.25 | 0.92 | 0.28 | 11 |
| Late(49w) - Male | 3.98 | 3.87 | 0.5 | 0.17 | 9 |
| Signif. codes ***: <0.001 **: <0.010 *: <0.050 †: <0.100 |
||||||
| Factor | df | Sum Sq. | F value | Pr(>F) | Signif. | |
|---|---|---|---|---|---|---|
| condition1 | 1 | 21.089 | 27.0649 | 5.204e-06 | *** | |
| sex | 1 | 15.811 | 20.2917 | 5.032e-05 | *** | |
| condition1:sex | 1 | 0.479 | 0.6142 | 0.4375 | ||
| Residuals | 43 | 33.506 | ||||
| Level | Difference | Lower | Upper | Adjusted p |
|---|---|---|---|---|
| Late(49w) - Early(9w) | -1.32 | -1.84 | -0.794 | 8.2e-06 |
| Level | Difference | Lower | Upper | Adjusted p |
|---|---|---|---|---|
| Male - Female | -1.16 | -1.68 | -0.641 | 5.07e-05 |
| comment |
|---|
| Forelimb and hindlimb grip strength normalised against body weight was significantly decreased in 49-week-old mice (Late) relative to 9-week-old mice (Early) (p<0.01). |