|Japan Mouse Clinic is one of institutional members of IMPC (International Mouse Phenotyping Consortium) .|
|Enter the page “Activity for IMPC” to search phenotype and development information of IMPC Knockout mouse strains.|
The collaborative research team consisting of Kyoto University (Dr. Naruse C. and Prof. Asano M.), Osaka University (Prof. Ikawa M.) and The Japan Mouse Clinic found that the demethylase activity of Jmjd3, which tightly regulates the expression of Hox cluster genes, is critical for the vertebra and rib development in the mouse. This result was published in the “FASEB Journal” (http://doi.org/10.1096/fj.201600642R).
Progress of phenotyping JMC was updated.
Prof. Osumi and Dr. Yoshizaki of Tohoku University and The Japan Mouse Clinic team indicate that mice with a single genetic risk factor can develop different phenotypes with behavioral abnormalities depending on the paternal age. Our study advocates for serious considerations on the role of paternal aging in breeding strategies for animal studies. This result is published in the online issue of PLOS ONE on November 18th.
|2016/11/07:||University of Tsukuba WPI-IIIS group (Drs. Funato and Yanagisawa) and The Japan Mouse Clinic team use genetic screening approach ( ENU mutagenesis ) for identify mutations that affect sleep/wakefulness in mice. This landmark paper was published in the issue of Nature on November 17th.
|2016/10/25:||The phenotyping pipeline 1 on the Japan Mouse Clinic has been reestablished.|
The International Mouse Phenotyping Consortium (IMPC) identified 410 genes that are essential to life in the mouse through the comprehensive phenotyping of 1751 KO mouse lines. The results have been published in Nature (22nd September 2016) and will provide invaluable data set to investigate gene function and contribute to conquer human intractable diseases.
|2016/08/22:||The Japan Mouse Clinic has planed the late-onset phenotyping pipeline which is performed on 49 wks to 56 wks.|
The Fifth RIKEN BRC-Nanjing University MARC Mouse Resource Workshop will be co-organized by RIKEN BioResource Center and Nanjing University Model Animal Research Center.
In the course, the SHIRPA workshop will be operated by the Japan Mouse Clinic.
Date: July 25 - 27, 2016
Place: RIKEN BioResource Center(BRC)
Registraion Fee: Free
Official Language: English
|2016/04/11:||The Modified SHIRPA Technical Training Course was launched in the RIKEN BioResource Center.|
|2016/03/01:||Progress of phenotyping JMC was updated.|
The technical training course of the RIKEN Modified
SHIRPA was launched in the RIKEN BioResource Center.
Phenotype criteria with movies and images of Combined Modified SHIRPA and Dysmorphology (CSD) have been added in the RIKEN Modified SHIRPA homepage.