Procedure Combined SHIRPA and Dysmorphology v1.1
Pipeline IMPC_adult_v2-LaterOnset Screen Age (week) 9-49w
Parameter Group Body size
Parameter Body mass index (BMI)
Strain Condition 1 Pipeline(s) Tested Day
(Age)
IMPC_adult_v2-LaterOnset
C57BL/6NJcl Late ♀: 11  ♂: 9 2015/10/06 - 2016/07/12
(9.36 - 49.93)
Early ♀: 14  ♂: 13
Raw Data

Bartlett test result
Factor df Bartlett's K2 p
condition1 1 28.2223 1.081514e-07
sex 1 0.873847 0.3498925

Summary statistics
Factor mean median SD SEM N
condition1 - sex
Early(9w) - Female 2.28 2.27 0.11 0.03 14
Early(9w) - Male 2.59 2.6 0.15 0.04 13
Late(49w) - Female 3.18 2.86 0.66 0.2 11
Late(49w) - Male 4.05 4.18 0.32 0.11 9

ANOVA result
Signif. codes ***: <0.001
**: <0.010
*: <0.050
†: <0.100
Factor df Sum Sq. F value Pr(>F) Signif.
condition1 1 15.3910 119.4258 5.451e-14 ***
sex 1 3.5594 27.6192 4.368e-06 ***
condition1:sex 1 0.8753 6.7922 0.01253 *
Residuals 43 5.5416

Tukey multiple comparisons of means
Factor: condition1
Level Difference Lower Upper Adjusted p
Late(49w) - Early(9w) 1.14 0.927 1.35 1.21e-12

Factor: sex
Level Difference Lower Upper Adjusted p
Male - Female 0.551 0.340 0.763 4.41e-06

Factor: condition1:sex
Level Difference Lower Upper Adjusted p
Late(49w):Female - Early(9w):Female 0.901 0.5148 1.288 9.90e-07
Early(9w):Male - Early(9w):Female 0.317 -0.0522 0.687 1.15e-01
Late(49w):Male - Early(9w):Female 1.772 1.3626 2.182 1.17e-12
Early(9w):Male - Late(49w):Female -0.584 -0.9771 -0.191 1.48e-03
Late(49w):Male - Late(49w):Female 0.871 0.4399 1.302 1.58e-05
Late(49w):Male - Early(9w):Male 1.455 1.0392 1.871 3.94e-11



FM_02_U_barchart.png

comment
BMI was significantly increased in 49-week-old mice (Late) relative to 9-week-old mice (Early) in both sexes (p<0.01).