| Procedure | Pathology | ||
|---|---|---|---|
| Pipeline | IMPC_adult_v2-LaterOnset | Screen Age (week) | 16-56w |
| Parameter Group | Heart (weight) | ||
| Parameter | Heart weight to body weight ratio | ||
| Strain | Condition 1 | Pipeline(s) | Tested Day (Age) |
|---|---|---|---|
| IMPC_adult_v2-LaterOnset | |||
| C57BL/6NJcl | Late | ♀: 11 ♂: 9 |
2015/11/26 - 2016/08/31 (17.07 - 56.93) |
| Early | ♀: 3 ♂: 3 |
| Factor | df | Bartlett's K2 | p |
|---|---|---|---|
| condition1 | 1 | 0.1668412 | 0.6829345 |
| sex | 1 | 0.06112564 | 0.8047256 |
| Factor | mean | median | SD | SEM | N |
|---|---|---|---|---|---|
| condition1 - sex | |||||
| Early(16w) - Female | 4.78 | 4.66 | 0.39 | 0.23 | 3 |
| Early(16w) - Male | 4.73 | 4.9 | 0.58 | 0.33 | 3 |
| Late(56w) - Female | 3.83 | 4.04 | 0.44 | 0.13 | 11 |
| Late(56w) - Male | 3.54 | 3.43 | 0.23 | 0.08 | 9 |
| Signif. codes ***: <0.001 **: <0.010 *: <0.050 †: <0.100 |
||||||
| Factor | df | Sum Sq. | F value | Pr(>F) | Signif. | |
|---|---|---|---|---|---|---|
| condition1 | 1 | 5.2440 | 34.4192 | 6.655e-06 | *** | |
| sex | 1 | 0.3424 | 2.2471 | 0.1481 | ||
| condition1:sex | 1 | 0.0695 | 0.4562 | 0.5064 | ||
| Residuals | 22 | 3.3519 | ||||
| Level | Difference | Lower | Upper | Adjusted p |
|---|---|---|---|---|
| Late(56w) - Early(16w) | -1.06 | -1.43 | -0.679 | 7.63e-06 |
| comment |
|---|
| Heart weight to body weight ratio(HW/BW) was significantly decreased in 56-week-old mice (Late) relative to 16-week-old mice (Early) (p<0.001). |