Procedure | Indirect Calorimetry v1 | ||
---|---|---|---|
Pipeline | IMPC_adult_v2-LaterOnset | Screen Age (week) | 11-51w |
Parameter | Total activity (no. of fine movement + no.of beam cuts) |
Strain | Condition 1 | Pipeline(s) | Tested Day (Age) |
---|---|---|---|
IMPC_adult_v2-LaterOnset | |||
C57BL/6NJcl | Late | ♀: 8 ♂: 8 |
2015/10/20 - 2016/07/26 (11.5 - 51.93) |
Early | ♀: 8 ♂: 8 |
Conditions of statistics.
Pairwise comparisons using t tests with pooled SD
|
Pair | p |
---|---|
Early(11w) - Late(51w) | 0 |
Pair | p |
---|---|
1 - 7 | 0.0065 |
1 - 8 | 0 |
1 - 9 | 0 |
1 - 10 | 4e-04 |
1 - 11 | 0.0112 |
2 - 7 | 0.0018 |
2 - 8 | 0 |
2 - 9 | 0 |
2 - 10 | 1e-04 |
2 - 11 | 0.0032 |
3 - 7 | 0.0035 |
3 - 8 | 0 |
3 - 9 | 0 |
3 - 10 | 2e-04 |
3 - 11 | 0.0061 |
4 - 7 | 0.0188 |
4 - 8 | 0 |
4 - 9 | 0 |
4 - 10 | 0.0014 |
4 - 11 | 0.0316 |
5 - 8 | 0 |
5 - 9 | 3e-04 |
5 - 10 | 0.0068 |
6 - 8 | 0 |
6 - 9 | 5e-04 |
6 - 10 | 0.0099 |
7 - 14 | 0.026 |
7 - 19 | 0.0212 |
7 - 21 | 0.001 |
8 - 13 | 1e-04 |
8 - 14 | 0 |
8 - 15 | 0 |
8 - 18 | 0.0088 |
8 - 19 | 0 |
8 - 20 | 0 |
8 - 21 | 0 |
9 - 13 | 0.0012 |
9 - 14 | 1e-04 |
9 - 15 | 6e-04 |
9 - 19 | 1e-04 |
9 - 20 | 2e-04 |
9 - 21 | 0 |
10 - 13 | 0.0236 |
10 - 14 | 0.002 |
10 - 15 | 0.0134 |
10 - 19 | 0.0016 |
10 - 20 | 0.0051 |
10 - 21 | 1e-04 |
11 - 14 | 0.0432 |
11 - 19 | 0.0354 |
11 - 21 | 0.0018 |
Pair | p |
---|---|
Early(11w):1 - Early(11w):10 | 0 |
Early(11w):1 - Early(11w):11 | 0 |
Early(11w):1 - Early(11w):7 | 0.0042 |
Early(11w):1 - Early(11w):8 | 0 |
Early(11w):1 - Early(11w):9 | 0 |
Early(11w):10 - Early(11w):13 | 2e-04 |
Early(11w):10 - Early(11w):14 | 0 |
Early(11w):10 - Early(11w):15 | 4e-04 |
Early(11w):10 - Early(11w):19 | 0 |
Early(11w):10 - Early(11w):2 | 0 |
Early(11w):10 - Early(11w):20 | 3e-04 |
Early(11w):10 - Early(11w):21 | 0 |
Early(11w):10 - Early(11w):3 | 0 |
Early(11w):10 - Early(11w):4 | 0 |
Early(11w):10 - Early(11w):5 | 0 |
Early(11w):10 - Early(11w):6 | 1e-04 |
Early(11w):10 - Late(51w):1 | 0 |
Early(11w):10 - Late(51w):10 | 0.002 |
Early(11w):10 - Late(51w):11 | 0 |
Early(11w):10 - Late(51w):12 | 3e-04 |
Early(11w):10 - Late(51w):13 | 0 |
Early(11w):10 - Late(51w):14 | 0 |
Early(11w):10 - Late(51w):15 | 0 |
Early(11w):10 - Late(51w):16 | 0 |
Early(11w):10 - Late(51w):17 | 0.0018 |
Early(11w):10 - Late(51w):18 | 0 |
Early(11w):10 - Late(51w):19 | 0 |
Early(11w):10 - Late(51w):2 | 0 |
Early(11w):10 - Late(51w):20 | 0 |
Early(11w):10 - Late(51w):21 | 0 |
Early(11w):10 - Late(51w):3 | 0 |
Early(11w):10 - Late(51w):4 | 0 |
Early(11w):10 - Late(51w):5 | 0 |
Early(11w):10 - Late(51w):6 | 0 |
Early(11w):10 - Late(51w):7 | 0.0376 |
Early(11w):11 - Early(11w):13 | 4e-04 |
Early(11w):11 - Early(11w):14 | 0 |
Early(11w):11 - Early(11w):15 | 8e-04 |
Early(11w):11 - Early(11w):19 | 0 |
Early(11w):11 - Early(11w):2 | 0 |
Early(11w):11 - Early(11w):20 | 6e-04 |
Early(11w):11 - Early(11w):21 | 0 |
Early(11w):11 - Early(11w):3 | 0 |
Early(11w):11 - Early(11w):4 | 0 |
Early(11w):11 - Early(11w):5 | 1e-04 |
Early(11w):11 - Early(11w):6 | 2e-04 |
Early(11w):11 - Late(51w):1 | 0 |
Early(11w):11 - Late(51w):10 | 0.0043 |
Early(11w):11 - Late(51w):11 | 0 |
Early(11w):11 - Late(51w):12 | 7e-04 |
Early(11w):11 - Late(51w):13 | 0 |
Early(11w):11 - Late(51w):14 | 0 |
Early(11w):11 - Late(51w):15 | 0 |
Early(11w):11 - Late(51w):16 | 0 |
Early(11w):11 - Late(51w):17 | 0.0039 |
Early(11w):11 - Late(51w):18 | 0 |
Early(11w):11 - Late(51w):19 | 0 |
Early(11w):11 - Late(51w):2 | 0 |
Early(11w):11 - Late(51w):20 | 0 |
Early(11w):11 - Late(51w):21 | 0 |
Early(11w):11 - Late(51w):3 | 0 |
Early(11w):11 - Late(51w):4 | 0 |
Early(11w):11 - Late(51w):5 | 0 |
Early(11w):11 - Late(51w):6 | 0 |
Early(11w):12 - Early(11w):21 | 0.0296 |
Early(11w):13 - Early(11w):8 | 0 |
Early(11w):13 - Early(11w):9 | 1e-04 |
Early(11w):14 - Early(11w):7 | 0.0271 |
Early(11w):14 - Early(11w):8 | 0 |
Early(11w):14 - Early(11w):9 | 0 |
Early(11w):15 - Early(11w):8 | 0 |
Early(11w):15 - Early(11w):9 | 3e-04 |
Early(11w):17 - Early(11w):21 | 0.0394 |
Early(11w):18 - Early(11w):8 | 0.0332 |
Early(11w):19 - Early(11w):7 | 0.0092 |
Early(11w):19 - Early(11w):8 | 0 |
Early(11w):19 - Early(11w):9 | 0 |
Early(11w):2 - Early(11w):7 | 7e-04 |
Early(11w):2 - Early(11w):8 | 0 |
Early(11w):2 - Early(11w):9 | 0 |
Early(11w):20 - Early(11w):8 | 0 |
Early(11w):20 - Early(11w):9 | 2e-04 |
Early(11w):21 - Early(11w):7 | 3e-04 |
Early(11w):21 - Early(11w):8 | 0 |
Early(11w):21 - Early(11w):9 | 0 |
Early(11w):3 - Early(11w):7 | 0.0015 |
Early(11w):3 - Early(11w):8 | 0 |
Early(11w):3 - Early(11w):9 | 0 |
Early(11w):4 - Early(11w):7 | 0.0098 |
Early(11w):4 - Early(11w):8 | 0 |
Early(11w):4 - Early(11w):9 | 0 |
Early(11w):5 - Early(11w):8 | 0 |
Early(11w):5 - Early(11w):9 | 0 |
Early(11w):6 - Early(11w):8 | 0 |
Early(11w):6 - Early(11w):9 | 1e-04 |
Early(11w):7 - Late(51w):1 | 0.0037 |
Early(11w):7 - Late(51w):11 | 0.0306 |
Early(11w):7 - Late(51w):13 | 0.0356 |
Early(11w):7 - Late(51w):14 | 0.0065 |
Early(11w):7 - Late(51w):15 | 0.007 |
Early(11w):7 - Late(51w):16 | 0.0312 |
Early(11w):7 - Late(51w):18 | 0.0293 |
Early(11w):7 - Late(51w):19 | 0.0136 |
Early(11w):7 - Late(51w):2 | 0.0025 |
Early(11w):7 - Late(51w):20 | 0.0017 |
Early(11w):7 - Late(51w):21 | 0.0018 |
Early(11w):7 - Late(51w):3 | 0.0034 |
Early(11w):7 - Late(51w):4 | 0.0104 |
Early(11w):7 - Late(51w):5 | 0.022 |
Early(11w):7 - Late(51w):6 | 0.013 |
Early(11w):8 - Late(51w):1 | 0 |
Early(11w):8 - Late(51w):10 | 1e-04 |
Early(11w):8 - Late(51w):11 | 0 |
Early(11w):8 - Late(51w):12 | 0 |
Early(11w):8 - Late(51w):13 | 0 |
Early(11w):8 - Late(51w):14 | 0 |
Early(11w):8 - Late(51w):15 | 0 |
Early(11w):8 - Late(51w):16 | 0 |
Early(11w):8 - Late(51w):17 | 1e-04 |
Early(11w):8 - Late(51w):18 | 0 |
Early(11w):8 - Late(51w):19 | 0 |
Early(11w):8 - Late(51w):2 | 0 |
Early(11w):8 - Late(51w):20 | 0 |
Early(11w):8 - Late(51w):21 | 0 |
Early(11w):8 - Late(51w):3 | 0 |
Early(11w):8 - Late(51w):4 | 0 |
Early(11w):8 - Late(51w):5 | 0 |
Early(11w):8 - Late(51w):6 | 0 |
Early(11w):8 - Late(51w):7 | 0.0027 |
Early(11w):8 - Late(51w):9 | 0.0186 |
Early(11w):9 - Late(51w):1 | 0 |
Early(11w):9 - Late(51w):10 | 0.0017 |
Early(11w):9 - Late(51w):11 | 0 |
Early(11w):9 - Late(51w):12 | 3e-04 |
Early(11w):9 - Late(51w):13 | 0 |
Early(11w):9 - Late(51w):14 | 0 |
Early(11w):9 - Late(51w):15 | 0 |
Early(11w):9 - Late(51w):16 | 0 |
Early(11w):9 - Late(51w):17 | 0.0015 |
Early(11w):9 - Late(51w):18 | 0 |
Early(11w):9 - Late(51w):19 | 0 |
Early(11w):9 - Late(51w):2 | 0 |
Early(11w):9 - Late(51w):20 | 0 |
Early(11w):9 - Late(51w):21 | 0 |
Early(11w):9 - Late(51w):3 | 0 |
Early(11w):9 - Late(51w):4 | 0 |
Early(11w):9 - Late(51w):5 | 0 |
Early(11w):9 - Late(51w):6 | 0 |
Early(11w):9 - Late(51w):7 | 0.032 |
sex | Male |
---|
Factor | df | Bartlett's K2 | p |
---|---|---|---|
condition1 | 1 | 53.48064 | 2.611544e-13 |
within | 20 | 103.9634 | 2.443959e-13 |
Factor | Mauchly's W | p |
---|
Factor | mean | median | SD | SEM | N |
---|---|---|---|---|---|
condition1 - within | |||||
Early(11w) - 1 | 119.62 | 63.5 | 143.3 | 50.67 | 8 |
Early(11w) - 2 | 156.62 | 56 | 248.3 | 87.79 | 8 |
Early(11w) - 3 | 113.62 | 40.5 | 184.47 | 65.22 | 8 |
Early(11w) - 4 | 130 | 76.5 | 118.88 | 42.03 | 8 |
Early(11w) - 5 | 67 | 44 | 50.02 | 17.69 | 8 |
Early(11w) - 6 | 465.62 | 487.5 | 273.24 | 96.61 | 8 |
Early(11w) - 7 | 882.25 | 923.5 | 448.85 | 158.69 | 8 |
Early(11w) - 8 | 706.75 | 750 | 414.95 | 146.71 | 8 |
Early(11w) - 9 | 448.75 | 405.5 | 266.03 | 94.05 | 8 |
Early(11w) - 10 | 416.38 | 353.5 | 262.63 | 92.85 | 8 |
Early(11w) - 11 | 448.5 | 363.5 | 347.33 | 122.8 | 8 |
Early(11w) - 12 | 431.62 | 458 | 298.4 | 105.5 | 8 |
Early(11w) - 13 | 440.62 | 433 | 259.05 | 91.59 | 8 |
Early(11w) - 14 | 206.75 | 123 | 228.3 | 80.72 | 8 |
Early(11w) - 15 | 159.75 | 131 | 122.81 | 43.42 | 8 |
Early(11w) - 16 | 688.38 | 607 | 362.29 | 128.09 | 8 |
Early(11w) - 17 | 491.25 | 429 | 232.58 | 82.23 | 8 |
Early(11w) - 18 | 563.5 | 415.5 | 564.57 | 199.6 | 8 |
Early(11w) - 19 | 69.12 | 66.5 | 55.5 | 19.62 | 8 |
Early(11w) - 20 | 163.62 | 138.5 | 133.39 | 47.16 | 8 |
Early(11w) - 21 | 250.5 | 205.5 | 254.72 | 90.06 | 8 |
Late(51w) - 1 | 131.75 | 71.5 | 155.13 | 54.85 | 8 |
Late(51w) - 2 | 112.38 | 105 | 102.83 | 36.36 | 8 |
Late(51w) - 3 | 157.88 | 29.5 | 207.46 | 73.35 | 8 |
Late(51w) - 4 | 104 | 70.5 | 114.58 | 40.51 | 8 |
Late(51w) - 5 | 195.75 | 151 | 199.35 | 70.48 | 8 |
Late(51w) - 6 | 210.75 | 167.5 | 178.23 | 63.01 | 8 |
Late(51w) - 7 | 534.38 | 482.5 | 323.26 | 114.29 | 8 |
Late(51w) - 8 | 236.38 | 145.5 | 217.76 | 76.99 | 8 |
Late(51w) - 9 | 328.25 | 246 | 265.33 | 93.81 | 8 |
Late(51w) - 10 | 221.88 | 236 | 133.65 | 47.25 | 8 |
Late(51w) - 11 | 146.25 | 109 | 130.65 | 46.19 | 8 |
Late(51w) - 12 | 110.12 | 59.5 | 183.06 | 64.72 | 8 |
Late(51w) - 13 | 114.12 | 120 | 96.46 | 34.1 | 8 |
Late(51w) - 14 | 263 | 190 | 265.54 | 93.88 | 8 |
Late(51w) - 15 | 216 | 169 | 147.68 | 52.21 | 8 |
Late(51w) - 16 | 216.38 | 211.5 | 138.29 | 48.89 | 8 |
Late(51w) - 17 | 379.62 | 394 | 146.31 | 51.73 | 8 |
Late(51w) - 18 | 249 | 215 | 192.57 | 68.08 | 8 |
Late(51w) - 19 | 181.25 | 161 | 121.91 | 43.1 | 8 |
Late(51w) - 20 | 157 | 192 | 89.35 | 31.59 | 8 |
Late(51w) - 21 | 158.88 | 156.5 | 101.2 | 35.78 | 8 |
Signif. codes ***: <0.001 **: <0.010 *: <0.050 : <0.100 |
||||||
Factor | df | Sum Sq. | Mean Sq. | F value | Pr(>F) | Signif. |
---|---|---|---|---|---|---|
condition1 | 1 | 1708861 | 1708861 | 11.9515 | 0.00385 | ** |
Residuals | 14 | 2001758 | 142983 | |||
within | 20 | 7614263 | 380713 | 7.4864 | 2.2e-16 | *** |
condition1:within | 20 | 2865980 | 143299 | 2.8178 | 8.232e-05 | *** |
Residuals | 280 | 14239146 | 50854 | |||
Pair | p |
---|---|
Early(11w) - Late(51w) | 0 |
Pair | p |
---|---|
1 - 7 | 0 |
1 - 8 | 0.0357 |
2 - 7 | 0 |
3 - 7 | 0 |
4 - 7 | 0 |
4 - 8 | 0.0246 |
5 - 7 | 0 |
5 - 8 | 0.0454 |
6 - 7 | 0.0124 |
7 - 10 | 0.0052 |
7 - 11 | 0.0018 |
7 - 12 | 5e-04 |
7 - 13 | 7e-04 |
7 - 14 | 1e-04 |
7 - 15 | 0 |
7 - 19 | 0 |
7 - 20 | 0 |
7 - 21 | 0 |
8 - 19 | 0.0349 |
Pair | p |
---|---|
Early(11w):1 - Early(11w):16 | 0.0018 |
Early(11w):1 - Early(11w):7 | 0 |
Early(11w):1 - Early(11w):8 | 9e-04 |
Early(11w):14 - Early(11w):16 | 0.0464 |
Early(11w):14 - Early(11w):7 | 0 |
Early(11w):14 - Early(11w):8 | 0.0243 |
Early(11w):15 - Early(11w):16 | 0.0085 |
Early(11w):15 - Early(11w):7 | 0 |
Early(11w):15 - Early(11w):8 | 0.0042 |
Early(11w):16 - Early(11w):19 | 2e-04 |
Early(11w):16 - Early(11w):2 | 0.0076 |
Early(11w):16 - Early(11w):20 | 0.0098 |
Early(11w):16 - Early(11w):3 | 0.0014 |
Early(11w):16 - Early(11w):4 | 0.0027 |
Early(11w):16 - Early(11w):5 | 2e-04 |
Early(11w):16 - Late(51w):1 | 0.0029 |
Early(11w):16 - Late(51w):11 | 0.0051 |
Early(11w):16 - Late(51w):12 | 0.0012 |
Early(11w):16 - Late(51w):13 | 0.0015 |
Early(11w):16 - Late(51w):19 | 0.0188 |
Early(11w):16 - Late(51w):2 | 0.0014 |
Early(11w):16 - Late(51w):20 | 0.0077 |
Early(11w):16 - Late(51w):21 | 0.0082 |
Early(11w):16 - Late(51w):3 | 0.0079 |
Early(11w):16 - Late(51w):4 | 0.001 |
Early(11w):16 - Late(51w):5 | 0.0315 |
Early(11w):18 - Early(11w):19 | 0.0296 |
Early(11w):18 - Early(11w):5 | 0.0275 |
Early(11w):19 - Early(11w):7 | 0 |
Early(11w):19 - Early(11w):8 | 1e-04 |
Early(11w):2 - Early(11w):7 | 0 |
Early(11w):2 - Early(11w):8 | 0.0038 |
Early(11w):20 - Early(11w):7 | 0 |
Early(11w):20 - Early(11w):8 | 0.0049 |
Early(11w):21 - Early(11w):7 | 1e-04 |
Early(11w):3 - Early(11w):7 | 0 |
Early(11w):3 - Early(11w):8 | 7e-04 |
Early(11w):4 - Early(11w):7 | 0 |
Early(11w):4 - Early(11w):8 | 0.0013 |
Early(11w):5 - Early(11w):7 | 0 |
Early(11w):5 - Early(11w):8 | 1e-04 |
Early(11w):7 - Late(51w):1 | 0 |
Early(11w):7 - Late(51w):10 | 0 |
Early(11w):7 - Late(51w):11 | 0 |
Early(11w):7 - Late(51w):12 | 0 |
Early(11w):7 - Late(51w):13 | 0 |
Early(11w):7 - Late(51w):14 | 2e-04 |
Early(11w):7 - Late(51w):15 | 0 |
Early(11w):7 - Late(51w):16 | 0 |
Early(11w):7 - Late(51w):17 | 0.0221 |
Early(11w):7 - Late(51w):18 | 1e-04 |
Early(11w):7 - Late(51w):19 | 0 |
Early(11w):7 - Late(51w):2 | 0 |
Early(11w):7 - Late(51w):20 | 0 |
Early(11w):7 - Late(51w):21 | 0 |
Early(11w):7 - Late(51w):3 | 0 |
Early(11w):7 - Late(51w):4 | 0 |
Early(11w):7 - Late(51w):5 | 0 |
Early(11w):7 - Late(51w):6 | 0 |
Early(11w):7 - Late(51w):8 | 1e-04 |
Early(11w):7 - Late(51w):9 | 0.0032 |
Early(11w):8 - Late(51w):1 | 0.0014 |
Early(11w):8 - Late(51w):10 | 0.0414 |
Early(11w):8 - Late(51w):11 | 0.0025 |
Early(11w):8 - Late(51w):12 | 6e-04 |
Early(11w):8 - Late(51w):13 | 7e-04 |
Early(11w):8 - Late(51w):15 | 0.0337 |
Early(11w):8 - Late(51w):16 | 0.0341 |
Early(11w):8 - Late(51w):19 | 0.0096 |
Early(11w):8 - Late(51w):2 | 6e-04 |
Early(11w):8 - Late(51w):20 | 0.0038 |
Early(11w):8 - Late(51w):21 | 0.0041 |
Early(11w):8 - Late(51w):3 | 0.0039 |
Early(11w):8 - Late(51w):4 | 5e-04 |
Early(11w):8 - Late(51w):5 | 0.0163 |
Early(11w):8 - Late(51w):6 | 0.028 |
comment |
---|
Total activity (no. of fine movement + no.of beam cuts) was significantly decreased in 51-week-old mice (Late) relative to 11-week-old mice (Early) in both sexs (p<0.01). |