Procedure | Indirect Calorimetry v1 | ||
---|---|---|---|
Pipeline | IMPC_adult_v2-LaterOnset | Screen Age (week) | 11-51w |
Parameter | Ambulatory activity (no. of beam cuts) |
Strain | Condition 1 | Pipeline(s) | Tested Day (Age) |
---|---|---|---|
IMPC_adult_v2-LaterOnset | |||
C57BL/6NJcl | Late | ♀: 8 ♂: 8 |
2015/10/20 - 2016/07/26 (11.5 - 51.93) |
Early | ♀: 8 ♂: 8 |
Conditions of statistics.
Pairwise comparisons using t tests with pooled SD
|
Pair | p |
---|---|
Early(11w) - Late(51w) | 0 |
Pair | p |
---|---|
1 - 7 | 0.0065 |
1 - 8 | 0 |
1 - 9 | 0 |
1 - 10 | 4e-04 |
1 - 11 | 0.0112 |
2 - 7 | 0.0018 |
2 - 8 | 0 |
2 - 9 | 0 |
2 - 10 | 1e-04 |
2 - 11 | 0.0032 |
3 - 7 | 0.0035 |
3 - 8 | 0 |
3 - 9 | 0 |
3 - 10 | 2e-04 |
3 - 11 | 0.0061 |
4 - 7 | 0.0189 |
4 - 8 | 0 |
4 - 9 | 0 |
4 - 10 | 0.0014 |
4 - 11 | 0.0318 |
5 - 8 | 0 |
5 - 9 | 3e-04 |
5 - 10 | 0.0068 |
6 - 8 | 0 |
6 - 9 | 5e-04 |
6 - 10 | 0.0099 |
7 - 14 | 0.0261 |
7 - 19 | 0.0209 |
7 - 21 | 0.001 |
8 - 13 | 1e-04 |
8 - 14 | 0 |
8 - 15 | 0 |
8 - 18 | 0.0087 |
8 - 19 | 0 |
8 - 20 | 0 |
8 - 21 | 0 |
9 - 13 | 0.0012 |
9 - 14 | 1e-04 |
9 - 15 | 6e-04 |
9 - 19 | 1e-04 |
9 - 20 | 2e-04 |
9 - 21 | 0 |
10 - 13 | 0.0236 |
10 - 14 | 0.002 |
10 - 15 | 0.0134 |
10 - 19 | 0.0015 |
10 - 20 | 0.0051 |
10 - 21 | 1e-04 |
11 - 14 | 0.0435 |
11 - 19 | 0.0351 |
11 - 21 | 0.0018 |
Pair | p |
---|---|
Early(11w):1 - Early(11w):10 | 0 |
Early(11w):1 - Early(11w):11 | 0 |
Early(11w):1 - Early(11w):7 | 0.0042 |
Early(11w):1 - Early(11w):8 | 0 |
Early(11w):1 - Early(11w):9 | 0 |
Early(11w):10 - Early(11w):13 | 2e-04 |
Early(11w):10 - Early(11w):14 | 0 |
Early(11w):10 - Early(11w):15 | 4e-04 |
Early(11w):10 - Early(11w):19 | 0 |
Early(11w):10 - Early(11w):2 | 0 |
Early(11w):10 - Early(11w):20 | 3e-04 |
Early(11w):10 - Early(11w):21 | 0 |
Early(11w):10 - Early(11w):3 | 0 |
Early(11w):10 - Early(11w):4 | 0 |
Early(11w):10 - Early(11w):5 | 0 |
Early(11w):10 - Early(11w):6 | 1e-04 |
Early(11w):10 - Late(51w):1 | 0 |
Early(11w):10 - Late(51w):10 | 0.002 |
Early(11w):10 - Late(51w):11 | 0 |
Early(11w):10 - Late(51w):12 | 3e-04 |
Early(11w):10 - Late(51w):13 | 0 |
Early(11w):10 - Late(51w):14 | 0 |
Early(11w):10 - Late(51w):15 | 0 |
Early(11w):10 - Late(51w):16 | 0 |
Early(11w):10 - Late(51w):17 | 0.0018 |
Early(11w):10 - Late(51w):18 | 0 |
Early(11w):10 - Late(51w):19 | 0 |
Early(11w):10 - Late(51w):2 | 0 |
Early(11w):10 - Late(51w):20 | 0 |
Early(11w):10 - Late(51w):21 | 0 |
Early(11w):10 - Late(51w):3 | 0 |
Early(11w):10 - Late(51w):4 | 0 |
Early(11w):10 - Late(51w):5 | 0 |
Early(11w):10 - Late(51w):6 | 0 |
Early(11w):10 - Late(51w):7 | 0.0377 |
Early(11w):11 - Early(11w):13 | 4e-04 |
Early(11w):11 - Early(11w):14 | 0 |
Early(11w):11 - Early(11w):15 | 8e-04 |
Early(11w):11 - Early(11w):19 | 0 |
Early(11w):11 - Early(11w):2 | 0 |
Early(11w):11 - Early(11w):20 | 6e-04 |
Early(11w):11 - Early(11w):21 | 0 |
Early(11w):11 - Early(11w):3 | 0 |
Early(11w):11 - Early(11w):4 | 0 |
Early(11w):11 - Early(11w):5 | 1e-04 |
Early(11w):11 - Early(11w):6 | 2e-04 |
Early(11w):11 - Late(51w):1 | 0 |
Early(11w):11 - Late(51w):10 | 0.0043 |
Early(11w):11 - Late(51w):11 | 0 |
Early(11w):11 - Late(51w):12 | 7e-04 |
Early(11w):11 - Late(51w):13 | 0 |
Early(11w):11 - Late(51w):14 | 0 |
Early(11w):11 - Late(51w):15 | 0 |
Early(11w):11 - Late(51w):16 | 0 |
Early(11w):11 - Late(51w):17 | 0.0039 |
Early(11w):11 - Late(51w):18 | 0 |
Early(11w):11 - Late(51w):19 | 0 |
Early(11w):11 - Late(51w):2 | 0 |
Early(11w):11 - Late(51w):20 | 0 |
Early(11w):11 - Late(51w):21 | 0 |
Early(11w):11 - Late(51w):3 | 0 |
Early(11w):11 - Late(51w):4 | 0 |
Early(11w):11 - Late(51w):5 | 0 |
Early(11w):11 - Late(51w):6 | 0 |
Early(11w):12 - Early(11w):21 | 0.0294 |
Early(11w):13 - Early(11w):8 | 0 |
Early(11w):13 - Early(11w):9 | 1e-04 |
Early(11w):14 - Early(11w):7 | 0.0272 |
Early(11w):14 - Early(11w):8 | 0 |
Early(11w):14 - Early(11w):9 | 0 |
Early(11w):15 - Early(11w):8 | 0 |
Early(11w):15 - Early(11w):9 | 3e-04 |
Early(11w):17 - Early(11w):21 | 0.0396 |
Early(11w):18 - Early(11w):8 | 0.0328 |
Early(11w):19 - Early(11w):7 | 0.009 |
Early(11w):19 - Early(11w):8 | 0 |
Early(11w):19 - Early(11w):9 | 0 |
Early(11w):2 - Early(11w):7 | 7e-04 |
Early(11w):2 - Early(11w):8 | 0 |
Early(11w):2 - Early(11w):9 | 0 |
Early(11w):20 - Early(11w):8 | 0 |
Early(11w):20 - Early(11w):9 | 2e-04 |
Early(11w):21 - Early(11w):7 | 3e-04 |
Early(11w):21 - Early(11w):8 | 0 |
Early(11w):21 - Early(11w):9 | 0 |
Early(11w):3 - Early(11w):7 | 0.0015 |
Early(11w):3 - Early(11w):8 | 0 |
Early(11w):3 - Early(11w):9 | 0 |
Early(11w):4 - Early(11w):7 | 0.0098 |
Early(11w):4 - Early(11w):8 | 0 |
Early(11w):4 - Early(11w):9 | 0 |
Early(11w):5 - Early(11w):8 | 0 |
Early(11w):5 - Early(11w):9 | 0 |
Early(11w):6 - Early(11w):8 | 0 |
Early(11w):6 - Early(11w):9 | 1e-04 |
Early(11w):7 - Late(51w):1 | 0.0037 |
Early(11w):7 - Late(51w):11 | 0.0304 |
Early(11w):7 - Late(51w):13 | 0.0354 |
Early(11w):7 - Late(51w):14 | 0.0065 |
Early(11w):7 - Late(51w):15 | 0.007 |
Early(11w):7 - Late(51w):16 | 0.0312 |
Early(11w):7 - Late(51w):18 | 0.029 |
Early(11w):7 - Late(51w):19 | 0.0135 |
Early(11w):7 - Late(51w):2 | 0.0025 |
Early(11w):7 - Late(51w):20 | 0.0017 |
Early(11w):7 - Late(51w):21 | 0.0018 |
Early(11w):7 - Late(51w):3 | 0.0034 |
Early(11w):7 - Late(51w):4 | 0.0104 |
Early(11w):7 - Late(51w):5 | 0.0219 |
Early(11w):7 - Late(51w):6 | 0.013 |
Early(11w):8 - Late(51w):1 | 0 |
Early(11w):8 - Late(51w):10 | 1e-04 |
Early(11w):8 - Late(51w):11 | 0 |
Early(11w):8 - Late(51w):12 | 0 |
Early(11w):8 - Late(51w):13 | 0 |
Early(11w):8 - Late(51w):14 | 0 |
Early(11w):8 - Late(51w):15 | 0 |
Early(11w):8 - Late(51w):16 | 0 |
Early(11w):8 - Late(51w):17 | 1e-04 |
Early(11w):8 - Late(51w):18 | 0 |
Early(11w):8 - Late(51w):19 | 0 |
Early(11w):8 - Late(51w):2 | 0 |
Early(11w):8 - Late(51w):20 | 0 |
Early(11w):8 - Late(51w):21 | 0 |
Early(11w):8 - Late(51w):3 | 0 |
Early(11w):8 - Late(51w):4 | 0 |
Early(11w):8 - Late(51w):5 | 0 |
Early(11w):8 - Late(51w):6 | 0 |
Early(11w):8 - Late(51w):7 | 0.0027 |
Early(11w):8 - Late(51w):9 | 0.0182 |
Early(11w):9 - Late(51w):1 | 0 |
Early(11w):9 - Late(51w):10 | 0.0017 |
Early(11w):9 - Late(51w):11 | 0 |
Early(11w):9 - Late(51w):12 | 3e-04 |
Early(11w):9 - Late(51w):13 | 0 |
Early(11w):9 - Late(51w):14 | 0 |
Early(11w):9 - Late(51w):15 | 0 |
Early(11w):9 - Late(51w):16 | 0 |
Early(11w):9 - Late(51w):17 | 0.0015 |
Early(11w):9 - Late(51w):18 | 0 |
Early(11w):9 - Late(51w):19 | 0 |
Early(11w):9 - Late(51w):2 | 0 |
Early(11w):9 - Late(51w):20 | 0 |
Early(11w):9 - Late(51w):21 | 0 |
Early(11w):9 - Late(51w):3 | 0 |
Early(11w):9 - Late(51w):4 | 0 |
Early(11w):9 - Late(51w):5 | 0 |
Early(11w):9 - Late(51w):6 | 0 |
Early(11w):9 - Late(51w):7 | 0.032 |
sex | Male |
---|
Factor | df | Bartlett's K2 | p |
---|---|---|---|
condition1 | 1 | 53.45129 | 2.650843e-13 |
within | 20 | 103.9314 | 2.476635e-13 |
Factor | Mauchly's W | p |
---|
Factor | mean | median | SD | SEM | N |
---|---|---|---|---|---|
condition1 - within | |||||
Early(11w) - 1 | 118.5 | 63 | 143.03 | 50.57 | 8 |
Early(11w) - 2 | 155.75 | 54 | 248.07 | 87.71 | 8 |
Early(11w) - 3 | 113.25 | 40.5 | 184.17 | 65.12 | 8 |
Early(11w) - 4 | 129.62 | 76 | 118.89 | 42.04 | 8 |
Early(11w) - 5 | 66.5 | 43.5 | 49.94 | 17.66 | 8 |
Early(11w) - 6 | 465.25 | 487 | 273.42 | 96.67 | 8 |
Early(11w) - 7 | 881.62 | 923.5 | 448.59 | 158.6 | 8 |
Early(11w) - 8 | 705.62 | 750 | 414.89 | 146.69 | 8 |
Early(11w) - 9 | 448 | 404.5 | 265.73 | 93.95 | 8 |
Early(11w) - 10 | 415 | 352.5 | 263.37 | 93.11 | 8 |
Early(11w) - 11 | 447.5 | 361.5 | 347.16 | 122.74 | 8 |
Early(11w) - 12 | 429.75 | 457 | 299.77 | 105.99 | 8 |
Early(11w) - 13 | 439.62 | 432.5 | 258.85 | 91.52 | 8 |
Early(11w) - 14 | 204.88 | 118.5 | 228.48 | 80.78 | 8 |
Early(11w) - 15 | 159.38 | 131 | 122.93 | 43.46 | 8 |
Early(11w) - 16 | 688 | 607 | 362.61 | 128.2 | 8 |
Early(11w) - 17 | 490.25 | 428.5 | 232.76 | 82.29 | 8 |
Early(11w) - 18 | 562.75 | 415.5 | 563.26 | 199.14 | 8 |
Early(11w) - 19 | 67.88 | 64.5 | 54.87 | 19.4 | 8 |
Early(11w) - 20 | 162 | 137.5 | 133.25 | 47.11 | 8 |
Early(11w) - 21 | 249.38 | 203.5 | 254.98 | 90.15 | 8 |
Late(51w) - 1 | 131.12 | 70.5 | 155.19 | 54.87 | 8 |
Late(51w) - 2 | 111.75 | 105 | 103.02 | 36.42 | 8 |
Late(51w) - 3 | 157.38 | 29 | 207.69 | 73.43 | 8 |
Late(51w) - 4 | 103.88 | 70.5 | 114.69 | 40.55 | 8 |
Late(51w) - 5 | 195.5 | 151 | 199.4 | 70.5 | 8 |
Late(51w) - 6 | 210 | 167 | 177.57 | 62.78 | 8 |
Late(51w) - 7 | 533.88 | 482.5 | 323.58 | 114.4 | 8 |
Late(51w) - 8 | 236.25 | 145.5 | 217.59 | 76.93 | 8 |
Late(51w) - 9 | 327.5 | 244 | 265.35 | 93.81 | 8 |
Late(51w) - 10 | 221.38 | 235 | 133.35 | 47.15 | 8 |
Late(51w) - 11 | 145.25 | 108.5 | 130.9 | 46.28 | 8 |
Late(51w) - 12 | 109.12 | 57 | 183.05 | 64.72 | 8 |
Late(51w) - 13 | 113.75 | 119 | 96.49 | 34.12 | 8 |
Late(51w) - 14 | 262.62 | 190 | 265.91 | 94.01 | 8 |
Late(51w) - 15 | 215.25 | 167.5 | 147.63 | 52.19 | 8 |
Late(51w) - 16 | 216.12 | 211.5 | 138.4 | 48.93 | 8 |
Late(51w) - 17 | 378.75 | 393.5 | 146.05 | 51.64 | 8 |
Late(51w) - 18 | 248.25 | 214.5 | 193.09 | 68.27 | 8 |
Late(51w) - 19 | 181 | 161 | 121.68 | 43.02 | 8 |
Late(51w) - 20 | 155.75 | 190 | 88.47 | 31.28 | 8 |
Late(51w) - 21 | 158.38 | 156.5 | 101.31 | 35.82 | 8 |
Signif. codes ***: <0.001 **: <0.010 *: <0.050 : <0.100 |
||||||
Factor | df | Sum Sq. | Mean Sq. | F value | Pr(>F) | Signif. |
---|---|---|---|---|---|---|
condition1 | 1 | 1700172 | 1700172 | 11.9073 | 0.003899 | ** |
Residuals | 14 | 1998982 | 142784 | |||
within | 20 | 7616851 | 380843 | 7.4891 | 2.2e-16 | *** |
condition1:within | 20 | 2866571 | 143329 | 2.8185 | 8.202e-05 | *** |
Residuals | 280 | 14238852 | 50853 | |||
Pair | p |
---|---|
Early(11w) - Late(51w) | 0 |
Pair | p |
---|---|
1 - 7 | 0 |
1 - 8 | 0.0352 |
2 - 7 | 0 |
3 - 7 | 0 |
4 - 7 | 0 |
4 - 8 | 0.0249 |
5 - 7 | 0 |
5 - 8 | 0.0457 |
6 - 7 | 0.0123 |
7 - 10 | 0.0051 |
7 - 11 | 0.0018 |
7 - 12 | 5e-04 |
7 - 13 | 7e-04 |
7 - 14 | 1e-04 |
7 - 15 | 0 |
7 - 19 | 0 |
7 - 20 | 0 |
7 - 21 | 0 |
8 - 19 | 0.0346 |
Pair | p |
---|---|
Early(11w):1 - Early(11w):16 | 0.0018 |
Early(11w):1 - Early(11w):7 | 0 |
Early(11w):1 - Early(11w):8 | 9e-04 |
Early(11w):14 - Early(11w):16 | 0.044 |
Early(11w):14 - Early(11w):7 | 0 |
Early(11w):14 - Early(11w):8 | 0.0236 |
Early(11w):15 - Early(11w):16 | 0.0085 |
Early(11w):15 - Early(11w):7 | 0 |
Early(11w):15 - Early(11w):8 | 0.0043 |
Early(11w):16 - Early(11w):19 | 2e-04 |
Early(11w):16 - Early(11w):2 | 0.0074 |
Early(11w):16 - Early(11w):20 | 0.0094 |
Early(11w):16 - Early(11w):3 | 0.0014 |
Early(11w):16 - Early(11w):4 | 0.0027 |
Early(11w):16 - Early(11w):5 | 2e-04 |
Early(11w):16 - Late(51w):1 | 0.0029 |
Early(11w):16 - Late(51w):11 | 0.005 |
Early(11w):16 - Late(51w):12 | 0.0012 |
Early(11w):16 - Late(51w):13 | 0.0015 |
Early(11w):16 - Late(51w):19 | 0.0188 |
Early(11w):16 - Late(51w):2 | 0.0013 |
Early(11w):16 - Late(51w):20 | 0.0074 |
Early(11w):16 - Late(51w):21 | 0.0082 |
Early(11w):16 - Late(51w):3 | 0.0079 |
Early(11w):16 - Late(51w):4 | 0.001 |
Early(11w):16 - Late(51w):5 | 0.0316 |
Early(11w):18 - Early(11w):19 | 0.0291 |
Early(11w):18 - Early(11w):5 | 0.0277 |
Early(11w):19 - Early(11w):7 | 0 |
Early(11w):19 - Early(11w):8 | 1e-04 |
Early(11w):2 - Early(11w):7 | 0 |
Early(11w):2 - Early(11w):8 | 0.0038 |
Early(11w):20 - Early(11w):7 | 0 |
Early(11w):20 - Early(11w):8 | 0.0048 |
Early(11w):21 - Early(11w):7 | 1e-04 |
Early(11w):3 - Early(11w):7 | 0 |
Early(11w):3 - Early(11w):8 | 7e-04 |
Early(11w):4 - Early(11w):7 | 0 |
Early(11w):4 - Early(11w):8 | 0.0014 |
Early(11w):5 - Early(11w):7 | 0 |
Early(11w):5 - Early(11w):8 | 1e-04 |
Early(11w):7 - Late(51w):1 | 0 |
Early(11w):7 - Late(51w):10 | 0 |
Early(11w):7 - Late(51w):11 | 0 |
Early(11w):7 - Late(51w):12 | 0 |
Early(11w):7 - Late(51w):13 | 0 |
Early(11w):7 - Late(51w):14 | 2e-04 |
Early(11w):7 - Late(51w):15 | 0 |
Early(11w):7 - Late(51w):16 | 0 |
Early(11w):7 - Late(51w):17 | 0.0218 |
Early(11w):7 - Late(51w):18 | 1e-04 |
Early(11w):7 - Late(51w):19 | 0 |
Early(11w):7 - Late(51w):2 | 0 |
Early(11w):7 - Late(51w):20 | 0 |
Early(11w):7 - Late(51w):21 | 0 |
Early(11w):7 - Late(51w):3 | 0 |
Early(11w):7 - Late(51w):4 | 0 |
Early(11w):7 - Late(51w):5 | 0 |
Early(11w):7 - Late(51w):6 | 0 |
Early(11w):7 - Late(51w):8 | 1e-04 |
Early(11w):7 - Late(51w):9 | 0.0032 |
Early(11w):8 - Late(51w):1 | 0.0014 |
Early(11w):8 - Late(51w):10 | 0.0423 |
Early(11w):8 - Late(51w):11 | 0.0025 |
Early(11w):8 - Late(51w):12 | 6e-04 |
Early(11w):8 - Late(51w):13 | 7e-04 |
Early(11w):8 - Late(51w):15 | 0.0341 |
Early(11w):8 - Late(51w):16 | 0.0352 |
Early(11w):8 - Late(51w):19 | 0.0099 |
Early(11w):8 - Late(51w):2 | 7e-04 |
Early(11w):8 - Late(51w):20 | 0.0038 |
Early(11w):8 - Late(51w):21 | 0.0042 |
Early(11w):8 - Late(51w):3 | 0.004 |
Early(11w):8 - Late(51w):4 | 5e-04 |
Early(11w):8 - Late(51w):5 | 0.0168 |
Early(11w):8 - Late(51w):6 | 0.0283 |
comment |
---|
Ambulatory activity (no. of beam cuts) was significantly decreased in 51-week-old mice (Late) relative to 11-week-old mice (Early) in both sexs (p<0.01). |