| Procedure | Acoustic startle and Pre-pulse Inhibition (PPI) v1 | ||
|---|---|---|---|
| Pipeline | IMPC_adult_v2-LaterOnset | Screen Age (week) | 10-50w |
| Parameter | % Pre-pulse inhibition - PPI4 | ||
| Strain | Condition 1 | Pipeline(s) | Tested Day (Age) |
|---|---|---|---|
| IMPC_adult_v2-LaterOnset | |||
| C57BL/6NJcl | Late | ♀: 11 ♂: 9 |
2015/10/13 - 2016/07/20 (10.36 - 51.07) |
| Early | ♀: 14 ♂: 13 |
| Factor | df | Bartlett's K2 | p |
|---|---|---|---|
| condition1 | 1 | 9.060985 | 0.002611213 |
| sex | 1 | 1.053783 | 0.3046375 |
| Factor | mean | median | SD | SEM | N |
|---|---|---|---|---|---|
| condition1 - sex | |||||
| Early(10w) - Female | 81.77 | 82.85 | 9.04 | 2.42 | 14 |
| Early(10w) - Male | 84.7 | 86.7 | 6.65 | 1.85 | 13 |
| Late(50w) - Female | 72.29 | 78.1 | 17.09 | 5.15 | 11 |
| Late(50w) - Male | 74.68 | 81.1 | 13.62 | 4.54 | 9 |
| Signif. codes ***: <0.001 **: <0.010 *: <0.050 †: <0.100 |
||||||
| Factor | df | Sum Sq. | F value | Pr(>F) | Signif. | |
|---|---|---|---|---|---|---|
| condition1 | 1 | 1087.0 | 7.7932 | 0.007793 | ** | |
| sex | 1 | 85.2 | 0.6107 | 0.438823 | ||
| condition1:sex | 1 | 0.8 | 0.0060 | 0.938594 | ||
| Residuals | 43 | 5997.7 | ||||
| Level | Difference | Lower | Upper | Adjusted p |
|---|---|---|---|---|
| Late(50w) - Early(10w) | -9.82 | -16.8 | -2.79 | 0.00729 |
| comment |
|---|
| % Pre-pulse inhibition - PPI4 was significantly increased in 50-week-old mice (Late) relative to 10-week-old mice (Early) (p<0.01). |