| Procedure | Acoustic startle and Pre-pulse Inhibition (PPI) v1 | ||
|---|---|---|---|
| Pipeline | IMPC_adult_v2-LaterOnset | Screen Age (week) | 10-50w |
| Parameter | % Pre-pulse inhibition - PPI1 | ||
| Strain | Condition 1 | Pipeline(s) | Tested Day (Age) |
|---|---|---|---|
| IMPC_adult_v2-LaterOnset | |||
| C57BL/6NJcl | Late | ♀: 11 ♂: 9 |
2015/10/13 - 2016/07/20 (10.36 - 51.07) |
| Early | ♀: 14 ♂: 13 |
| Factor | df | Bartlett's K2 | p |
|---|---|---|---|
| condition1 | 1 | 0.1138263 | 0.7358293 |
| sex | 1 | 0.92406 | 0.3364112 |
| Factor | mean | median | SD | SEM | N |
|---|---|---|---|---|---|
| condition1 - sex | |||||
| Early(10w) - Female | 41.64 | 49.2 | 27.78 | 7.43 | 14 |
| Early(10w) - Male | 41.39 | 45.1 | 21.41 | 5.94 | 13 |
| Late(50w) - Female | 51.09 | 60.4 | 26.78 | 8.07 | 11 |
| Late(50w) - Male | 66.16 | 67.1 | 13.74 | 4.58 | 9 |
| Signif. codes ***: <0.001 **: <0.010 *: <0.050 †: <0.100 |
||||||
| Factor | df | Sum Sq. | F value | Pr(>F) | Signif. | |
|---|---|---|---|---|---|---|
| condition1 | 1 | 3143.1 | 5.5808 | 0.02275 | * | |
| sex | 1 | 454.9 | 0.8078 | 0.37378 | ||
| condition1:sex | 1 | 668.8 | 1.1876 | 0.28189 | ||
| Residuals | 43 | 24217.3 | ||||
| Level | Difference | Lower | Upper | Adjusted p |
|---|---|---|---|---|
| Late(50w) - Early(10w) | 16.4 | 2.23 | 30.5 | 0.0243 |
| comment |
|---|
| % Pre-pulse inhibition - PPI1 was significantly increased in 50-week-old mice (Late) relative to 10-week-old mice (Early) (p<0.05). |