Procedure Acoustic startle and Pre-pulse Inhibition (PPI) v1
Pipeline IMPC_adult_v2-LaterOnset Screen Age (week) 10-50w
Strain Condition 1 Pipeline(s) Tested Day
(Age)
IMPC_adult_v2-LaterOnset
C57BL/6NJcl Late ♀: 11  ♂: 9 2015/10/13 - 2016/07/20
(10.36 - 51.07)
Early ♀: 14  ♂: 13
Parameter Difference Supplement
Response amplitude - BN NS
Response amplitude - PP1 S
Response amplitude - PP1 S S
Response amplitude - PP2 NS
Response amplitude - PP2 S S
Response amplitude - PP3 NS
Response amplitude - PP3 S S
Response amplitude - PP4 NS
Response amplitude - PP4 S S
% Pre-pulse inhibition - PPI1 S
% Pre-pulse inhibition - PPI2 NS
% Pre-pulse inhibition - PPI3 NS
% Pre-pulse inhibition - PPI4 S
% Pre-pulse inhibition - Global NS
Response amplitude - S S

F_01_U_barchart.png M_01_U_barchart.png

comment
Startle amplitude was decreased in 50-week-old mice (Late) relative to 10-week-old mice (Early).
PPI1 was increased in 50-week-old mice (Late) relative to 10-week-old mice (Early), but PPI4 was decreased conversely.