Eye Morphology [LA_EYE_002]

Purpose

To detect abnormalities in eye morphology.

Experimental Design

• Age at test: Week 53
• Sex: Both

Procedure

1. Examine the anterior of both eyes (e.g. with slit lamp) and record any abnormalities
2. Test the iris/pupil light response
3. Image abnormal eyes as a minimum or all eyes if capacity permits
4. Dilate both eyes
5. Examine the anterior and posterior of both dilated eyes (e.g. with slit lamp and ophthalmoscope) and record any abnormalities
6. Image abnormal eyes as a minimum or all eyes if capacity permits

Notes

1. Only the eye (usually Left eye) that was not used for retro-orbital bleeds at early adult should be examined.
2. As a minimum, all abnormalities should be imaged.
   1. Where capacity permits, all mice can be imaged
3. Majority of parameters can be analysed using the standard approach for assessing categorical data. To increase power for analysis purposes, where an abnormality is detected in the left, right or both eyes, the data may be combined to generate one "abnormal" category.

Parameters & Metadata