| Procedure | Electrocardiogram (ECG) v１ | ||
|---|---|---|---|
| Pipeline | IMPC_adult_v2-LaterOnset | Screen Age (week) | 12-52w |
| Parameter | QTc | ||
| Strain | Condition 1 | Pipeline(s) | Tested Day (Age) |
|---|---|---|---|
| IMPC_adult_v2-LaterOnset | |||
| C57BL/6NJcl | Late | ♀: 4 ♂: 4 |
2015/10/27 - 2016/08/02 (12.64 - 52.79) |
| Early | ♀: 5 ♂: 5 |
| Factor | df | Bartlett's K2 | p |
|---|---|---|---|
| condition1 | 1 | 0.4068756 | 0.5235596 |
| sex | 1 | 3.143265 | 0.07624107 |
| Factor | mean | median | SD | SEM | N |
|---|---|---|---|---|---|
| condition1 - sex | |||||
| Early(12w) - Female | 75.67 | 75.38 | 3.18 | 1.42 | 5 |
| Early(12w) - Male | 73.25 | 72.87 | 3.06 | 1.37 | 5 |
| Late(52w) - Female | 81.16 | 81.48 | 1.6 | 0.8 | 4 |
| Late(52w) - Male | 85.45 | 86.19 | 4.83 | 2.42 | 4 |
| Signif. codes ***: <0.001 **: <0.010 *: <0.050 †: <0.100 |
||||||
| Factor | df | Sum Sq. | F value | Pr(>F) | Signif. | |
|---|---|---|---|---|---|---|
| condition1 | 1 | 347.77 | 31.2863 | 6.623e-05 | *** | |
| sex | 1 | 1.44 | 0.1295 | 0.72433 | ||
| condition1:sex | 1 | 50.14 | 4.5107 | 0.05199 | † | |
| Residuals | 14 | 155.62 | ||||
| Level | Difference | Lower | Upper | Adjusted p |
|---|---|---|---|---|
| Late(52w) - Early(12w) | 8.85 | 5.45 | 12.2 | 6.62e-05 |
| comment |
|---|
| QTc was significantly increased in 52-week-old mice (Late) relative to 12-week-old mice (Early) (p<0.01). |