Procedure Indirect Calorimetry v1
Pipeline IMPC_adult_v2-LaterOnset Screen Age (week) 11-51w
Strain Condition 1 Pipeline(s) Tested Day
(Age)
IMPC_adult_v2-LaterOnset
C57BL/6NJcl Late ♀: 8  ♂: 8 2015/10/20 - 2016/07/26
(11.5 - 51.93)
Early ♀: 8  ♂: 8
Parameter Difference Supplement
Ambulatory activity (no. of beam cuts) S
Body weight after experiment S
Body weight before experiment S
Carbon dioxide production S
Cumulative food intake NS
Cumulative water intake S
Heat production (metaboric rate) S
Oxygen consumption S
Respiratory Exchange Ratio NS
Total activity (no. of fine movement + no.of beam cuts) S
Total food intake NS
Total water intake NS
comment
Activity was significantly decreased in 51-week-old mice (Late) relative to 11-week-old mice (Early) in both sexes.

Body weight was significantly increased in 51-week-old mice (Late) relative to 11-week-old mice (Early) in both sexes.

Heat production, O2 consumption and CO2 production were significantly increased in 51-week-old mice (Late) relative to 11-week-old mice (Early) in both sexes.